FIP1L1 and PAPOLA

Number of citations of the paper that reports this interaction (PubMedID 14749727)
51

Data Source:
BioGRID (pull down)

		FIP1L1	PAPOLA
Description		factor interacting with PAPOLA and CPSF1	poly(A) polymerase alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol MRNA Cleavage And Polyadenylation Specificity Factor Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Manganese Ion Binding Metal Ion Binding Poly(A) RNA Polymerase Activity
	Biological Process	MRNA Processing	MRNA Processing RNA 3'-end Processing MRNA 3'-end Processing Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Cytosolic MRNA Polyadenylation
Pathways		Transport of Mature mRNA Derived from an Intronless Transcript mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Signaling by cytosolic PDGFRA and PDGFRB fusion proteins	mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
Drugs			Cordycepin Triphosphate 3-sulfino-L-alanine Triphosphoric acid
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) DNA methylation (variation) ( 23725790) Lymphocyte count ( 32888494) Red blood cell count ( 28453575) Serum VEGFR2 concentration ( 25411163) Subcortical volume (MOSTest) ( 32665545)	Carboplatin disposition in epthelial ovarian cancer ( 29367611) Copper levels ( 26025379) Metabolite levels ( 23823483) Number of stillbirths in continuous marriage ( 30188897) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		31 interacting genes: APP CEBPA CPSF4 CSNK2A1 GOLGA2 HMGB1 LIG4 MIR128-2 MIR15B MIR16-2 MIR19A MIR19B1 MIR205 MIR221 MIR34A MIR34B MIR9-3 MIR92A1 MIR92A2 MIRLET7B MIRLET7G MIRLET7I NAA10 OGT PAPOLA PRMT2 PRMT6 SGTA SRPK2 WWOX ZMYND19	6 interacting genes: CPSF1 CPSF3 FIP1L1 SMAD2 SNRPA YWHAE
Entrez ID		81608	10914
HPRD ID		09646	10407
Ensembl ID		ENSG00000145216	ENSG00000090060
Uniprot IDs		A0A994J3I9 A0A994J3J1 A0A994J3K1 A0A994J3K5 A0A994J3L5 A0A994J3M0 A0A994J3P6 A0A994J3Q0 A0A994J3Q5 A0A994J3R0 A0A994J3R5 A0A994J3S0 A0A994J3S6 A0A994J3T5 A0A994J438 A0A994J442 A0A994J453 A0A994J458 A0A994J464 A0A994J469 A0A994J474 A0A994J6B4 A0A994J6C6 A0A994J6D3 A0A994J6D6 A0A994J6E0 A0A994J6E2 A0A994J6N5 A0A994J6P0 A0A994J6Q5 A0A994J6R0 H0Y8P7 Q6UN15	A0A0C4DGK1 G3XAH6 P51003
PDB IDs		7K95 7ZY4 7ZYH	8R8R
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Vasculature Development MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Sprouting Angiogenesis Regulation Of Sprouting Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Translation Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Inflammatory Response MRNA 3'-UTR Binding Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Signal Transduction Regulation Of Programmed Cell Death Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Negative Regulation Of Defense Response Regulation Of Macromolecule Metabolic Process Regulation Of Translation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Regulation Of Apoptotic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Cell Migration Regulation Of Gene Expression Regulation Of Cell Motility Regulation Of Defense Response	MRNA Cleavage And Polyadenylation Specificity Factor Complex RNA Processing MRNA Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway RNA Metabolic Process MRNA Metabolic Process RNA Binding Nucleic Acid Metabolic Process RNA 3'-end Processing Nucleobase-containing Compound Metabolic Process Macromolecule Metabolic Process Homomeric SMAD Protein Complex Regulation Of Heart Rate By Hormone Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Spliceosomal SnRNP Complex 5'-3' RNA Exonuclease Activity Odontoblast Differentiation Mesoderm Morphogenesis SMAD Protein Complex Pericardium Development Trophoblast Cell Migration U1 SnRNP Binding Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Phosphoserine Residue Binding Positive Regulation Of Toll-like Receptor Signaling Pathway MRNA 3'-end Processing By Stem-loop Binding And Cleavage Nucleus Heteromeric SMAD Protein Complex U1 SnRNA Binding Determination Of Left/right Asymmetry In Lateral Mesoderm Nucleoplasm Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Embryonic Foregut Morphogenesis Type I Transforming Growth Factor Beta Receptor Binding Nodal Signaling Pathway Co-SMAD Binding Secondary Palate Development Primary MiRNA Processing Ubiquitin Protein Ligase Binding Dorsal/ventral Axis Specification Endoderm Formation Calcium Channel Inhibitor Activity
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