CLPTM1L and KCNF1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CLPTM1L	KCNF1
Name		CLPTM1 like	potassium voltage-gated channel modifier subfamily F member 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endomembrane System Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex Ciliary Base
	Molecular Function	Protein Binding Phospholipid Scramblase Activity	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity
	Biological Process	Lipid Transport Apoptotic Process Plasma Membrane Phospholipid Scrambling	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Potassium Ion Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport Non-motile Cilium Assembly
Pathways		None	Voltage gated Potassium channels
Drugs		None	Enflurane Promethazine Miconazole
GWAS		Adenocarcinoma in never smokers ( 31009812 ) Basal cell carcinoma ( 19151717 33549134 27539887 ) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027 ) Bladder cancer ( 20972438 ) Cervical intraepithelial neoplasia grade 3 and invasive cervical cancer ( 33794208 ) Chronic lymphocytic leukemia ( 24292274 ) Colorectal cancer or advanced adenoma ( 30510241 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous melanoma or hair colour ( 32341527 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Lung adenocarcinoma ( 19836008 20700438 ) Lung cancer ( 18978790 28604730 18978787 19654303 ) Lung cancer in ever smokers ( 28604730 ) Lung cancer in never smokers ( 31009812 ) Melanoma ( 21983787 ) Nasopharyngeal carcinoma ( 26545403 27436580 ) Nevus count or cutaneous melanoma ( 32341527 ) Non-melanoma skin cancer ( 29739929 ) Oral cavity cancer ( 27749845 32276964 ) Pancreatic cancer ( 26098869 20101243 25086665 29422604 27579533 ) Prostate-specific antigen levels ( 30410027 28139693 ) Squamous cell lung carcinoma ( 28604730 ) Testicular germ cell cancer ( 20543847 ) Testicular germ cell tumor ( 23666240 28604732 ) Uveal melanoma ( 28781888 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: ADRB2 GK KCNF1	13 interacting genes: ALOX15B CLPTM1L FARS2 KCNG3 KCNG4 KCNH1 KCNV2 MCL1 OPRM1 SERP1 SLC39A7 TCEA2 TSPO
Entrez ID		81037	3754
HPRD ID		07480	04808
Ensembl ID		ENSG00000049656	ENSG00000162975
Uniprot IDs		Q96KA5	Q9H3M0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Potassium Channel Regulator Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Beta2-adrenergic Receptor Activity Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Positive Regulation Of Autophagosome Maturation Regulation Of Metal Ion Transport Heat Generation Adrenergic Receptor Activity Diet Induced Thermogenesis Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Phosphotransferase Activity, Alcohol Group As Acceptor Negative Regulation Of Multicellular Organism Growth Glycerol Metabolic Process Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Triglyceride Biosynthetic Process Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Adaptive Thermogenesis Bone Resorption Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Brown Fat Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Alcohol Catabolic Process Temperature Homeostasis Positive Regulation Of Protein-containing Complex Disassembly Response To Cold Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Bone Mineralization Ciliary Base Regulation Of Systemic Arterial Blood Pressure Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Blood Pressure	Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Monoatomic Ion Transport Monoatomic Ion Channel Complex Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Potassium Ion Transmembrane Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Channel Activity Transmembrane Transport Potassium Ion Transport Potassium Channel Regulator Activity Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Nitric Oxide Biosynthetic Process Action Potential Regulation Of Biological Quality Protein Homooligomerization Endocannabinoid Signaling Pathway Negative Regulation Of Corticosterone Secretion Cyclic Nucleotide Binding Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Protein Complex Oligomerization Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Potassium Ion Transmembrane Transport Membrane Linoleate 9S-lipoxygenase Activity Linoleate 13S-lipoxygenase Activity Arachidonate 15-lipoxygenase Activity Arachidonate 8(S)-lipoxygenase Activity Lipoxin A4 Biosynthetic Process Cannabinoid Biosynthetic Process Lipoxin Biosynthetic Process Lipoxin A4 Metabolic Process Cannabinoid Signaling Pathway Contact Inhibition Response To Vitamin B1 Regulation Of Metal Ion Transport BH Domain Binding Cellular Response To Morphine Phenylalanine-tRNA Ligase Activity Phenylalanyl-tRNA Aminoacylation Regulation Of Potassium Ion Transport Negative Regulation Of Glucocorticoid Secretion