STEAP3 and BAD

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		STEAP3	BAD
Description		STEAP3 metalloreductase	BCL2 associated agonist of cell death
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Multivesicular Body Plasma Membrane Endosome Membrane Membrane	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane BAD-BCL-2 Complex
	Molecular Function	Protein Binding Cupric Reductase (NADH) Activity Oxidoreductase Activity Heme Binding Identical Protein Binding Metal Ion Binding Ferric-chelate Reductase (NADPH) Activity FAD Binding	Protein Binding Phospholipid Binding Lipid Binding Protein Kinase Binding Protein Phosphatase Binding Cysteine-type Endopeptidase Activator Activity
	Biological Process	Monoatomic Ion Transport Iron Ion Transport Apoptotic Process Protein Secretion Copper Ion Import	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Glucose Homeostasis Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Type B Pancreatic Cell Proliferation Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Type B Pancreatic Cell Development
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release CDC42 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOF GTPase cycle Transferrin endocytosis and recycling	Activation of BAD and translocation to mitochondria Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK AKT phosphorylates targets in the cytosol Constitutive Signaling by AKT1 E17K in Cancer
Drugs			Navitoclax
Diseases
GWAS		Cocaine dependence ( 23958962) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Renal cell carcinoma x sex interaction ( 31231134)	Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Platelet count ( 22423221) Sarcoidosis ( 22837380) Vitiligo ( 27723757) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: BAD BNIP3L MTDH PKMYT1 SETD7 TPT1	46 interacting genes: ACTN2 AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CHEK1 CREB3L3 EWSR1 HRK KEAP1 KRT31 MAP2K5 MAPK8 MCL1 PAK1 PAK5 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		55240	572
HPRD ID		10285	04409
Ensembl ID		ENSG00000115107	ENSG00000002330
Uniprot IDs		B8ZZX6 Q658P3	Q92934
PDB IDs		2VNS 2VQ3	1G5J 7Q16
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Mitochondrial Membrane Permeability Apoptotic Mitochondrial Changes Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Membrane Permeability Regulation Of Autophagy Negative Regulation Of Ectoderm Development Regulation Of Programmed Cell Death Regulation Of Cellular Response To Stress Regulation Of Apoptotic Process BAD-BCL-2 Complex Positive Regulation Of Catabolic Process Positive Regulation Of Type B Pancreatic Cell Development Mitochondrial Membrane Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of G2/MI Transition Of Meiotic Cell Cycle Cellular Response To Oxygen Levels Regulation Of Intrinsic Apoptotic Signaling Pathway Peptidyl-lysine Dimethylation Positive Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Intercellular Canaliculus Regulation Of G2/MI Transition Of Meiotic Cell Cycle Negative Regulation Of Meiotic Cell Cycle Phase Transition Peptidyl-lysine Monomethylation Regulation Of Type B Pancreatic Cell Development Cellular Response To Nicotine Histone H3K4 Monomethyltransferase Activity Nucleolus Mitochondrial Outer Membrane Permeabilization Mitochondrion Organization Cysteine-type Endopeptidase Activator Activity Mitochondrial Protein Catabolic Process Positive Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Heterochromatin Organization Response To Hypoxia Regulation Of Cellular Response To Osmotic Stress Negative Regulation Of Membrane Potential Response To Decreased Oxygen Levels Regulation Of Response To Osmotic Stress Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Response To Oxygen Levels Lamin Binding Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death	Intracellular Signal Transduction Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Cellular Response To Stress Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Protein Kinase Activity Kinase Activity Apoptotic Mitochondrial Changes Release Of Cytochrome C From Mitochondria Cytosol Apoptotic Process Programmed Cell Death Cell Death Protein Phosphorylation Response To Stress TORC1 Signaling Regulation Of Cellular Component Organization Signal Transduction Phosphorylation Protein Sequestering Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cytoplasm Cellular Response To Starvation TOR Signaling Cellular Response To Nutrient Levels Mitochondrion Organization Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Protein Modification Process Response To Starvation Protein Domain Specific Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Protein Metabolic Process Phosphoserine Residue Binding Extrinsic Apoptotic Signaling Pathway Channel Activity Positive Regulation Of Programmed Cell Death Mitochondrial Outer Membrane Intracellular Signaling Cassette Bcl-2 Family Protein Complex Regulation Of Protein Localization Identical Protein Binding ATP Binding Intracellular Protein Localization Apoptotic Signaling Pathway
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