STEAP3 and BAD

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		STEAP3	BAD
Gene Name		STEAP family member 3, metalloreductase	BCL2-associated agonist of cell death
Image
Gene Ontology Annotations	Cellular Component	Multivesicular Body Plasma Membrane Endosome Membrane Integral Component Of Membrane	Mitochondrion Mitochondrial Outer Membrane Cytosol
	Molecular Function	Ferric-chelate Reductase Activity Protein Binding Cupric Reductase Activity Metal Ion Binding Ferric-chelate Reductase (NADPH) Activity	Protein Binding Phospholipid Binding Lipid Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase 2B Binding Protein Kinase B Binding Protein Heterodimerization Activity
	Biological Process	Cellular Iron Ion Homeostasis Apoptotic Process Cell Cycle Protein Secretion Copper Ion Import Transferrin Transport Transmembrane Transport Oxidation-reduction Process Ferric Iron Import Into Cell Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Exosomal Secretion	Release Of Cytochrome C From Mitochondria Glucose Catabolic Process Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Glucose Positive Regulation Of Autophagy Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Cytokine-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Response To Estradiol Response To Progesterone Positive Regulation Of Glucokinase Activity Response To Testosterone Response To Oleic Acid Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway Response To Drug Response To Hydrogen Peroxide Glucose Homeostasis Positive Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Type B Pancreatic Cell Proliferation Innate Immune Response Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Proteolysis ADP Metabolic Process ATP Metabolic Process Regulation Of Mitochondrial Membrane Permeability Pore Complex Assembly Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Epithelial Cell Proliferation Response To Glucocorticoid Response To Calcium Ion Positive Regulation Of Apoptotic Process By Virus Cellular Process Regulating Host Cell Cycle In Response To Virus Cellular Response To Chromate Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Lipid Cellular Response To Hypoxia Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Iron uptake and transport Transferrin endocytosis and recycling	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Activation of BH3-only proteins Signaling by EGFRvIII in Cancer AKT phosphorylates targets in the cytosol Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Programmed Cell Death Innate Immune System Intrinsic Pathway for Apoptosis Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome Cell death signalling via NRAGE, NRIF and NADE Signaling by Ligand-Responsive EGFR Variants in Cancer p75 NTR receptor-mediated signalling NGF signalling via TRKA from the plasma membrane BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Activation of BAD and translocation to mitochondria Signaling by EGFR NRAGE signals death through JNK Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Mean platelet volume ( 22423221) Sarcoidosis ( 22837380)
Protein-Protein Interactions		5 interactors: BAD BNIP3L PKMYT1 SETD7 TPT1	43 interactors: AKT1 ARAF BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BRAF CDKN1A CREB3L3 EWSR1 HRK KEAP1 MAP2K5 MAPK8 MCL1 PAK1 PAK7 PIM1 PIM2 PIM3 PPP1CA PPP3CA PRDX2 PRKACA PRKCI RAF1 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA5 S100A10 SFN SNCA STEAP3 SUMO2 WASF1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		55240	572
HPRD ID		10285	04409
Ensembl ID		ENSG00000115107	ENSG00000002330
Uniprot IDs		B8ZZX6 Q658P3	Q92934
PDB IDs		2VNS 2VQ3	1G5J
Enriched GO Terms of Interacting Partners?		Response To Virus Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Mitochondrial Membrane Organization Apoptotic Mitochondrial Changes Cellular Response To Chromate Response To Other Organism Response To Biotic Stimulus Positive Regulation Of Mitochondrial Membrane Potential Suppression By Virus Of Host Apoptotic Process Mitochondrial Transport Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Mitochondrial Protein Catabolic Process Negative Regulation Of Cell Death Positive Regulation Of Apoptotic Process By Virus Glucose Catabolic Process Positive Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Glucokinase Activity Peptidyl-lysine Monomethylation Response To Chromate Organelle Organization Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Cellular Process Regulating Host Cell Cycle In Response To Virus Cellular Response To Nicotine Apoptotic Signaling Pathway Mitochondrial Outer Membrane Permeabilization Regulation Of Apoptotic Process Response To Oleic Acid Pore Complex Assembly Modulation By Virus Of Host Process Peptidyl-lysine Dimethylation Type B Pancreatic Cell Proliferation Regulation Of Cell Death ADP Metabolic Process Mitochondrion Organization Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Virus Positive Regulation Of B Cell Differentiation Heterochromatin Organization Response To External Stimulus Positive Regulation Of Mitochondrial Membrane Permeability Modulation By Virus Of Host Morphology Or Physiology Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Killing Of Cells Of Other Organism	Regulation Of Apoptotic Process Regulation Of Cell Death Apoptotic Process Programmed Cell Death Cell Death Death Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Intracellular Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cell Death Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Regulation Of Cellular Localization Phosphorylation Regulation Of Cellular Process Protein Phosphorylation Regulation Of Protein Metabolic Process Regulation Of Protein Localization Cellular Response To Stress Regulation Of Cellular Protein Metabolic Process Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Organic Substance Signal Transduction Cellular Response To Stimulus Cell Communication Phosphate-containing Compound Metabolic Process
Tagcloud ?			androgen bak bax colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
Tagcloud (Difference) ?			androgen bak bax colocalization dawley die dimethanesulfonate eds ethane fas fragmented germ governing hydroxysteroid killed leydig pachytene postinjection programmed sertoli spermatids spermatocytes spermatogenesis spermatogenic sprague testes withdraw withdrawal xl
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