STEAP3

Description		STEAP3 metalloreductase
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GO Annotations	Cellular Component	Cytoplasm Endosome Multivesicular Body Plasma Membrane Endosome Membrane Membrane
	Molecular Function	Protein Binding Cupric Reductase (NADH) Activity Oxidoreductase Activity Heme Binding Identical Protein Binding Metal Ion Binding Ferric-chelate Reductase (NADPH) Activity FAD Binding
	Biological Process	Monoatomic Ion Transport Iron Ion Transport Apoptotic Process Protein Secretion Copper Ion Import
Pathways		TP53 Regulates Transcription of Genes Involved in Cytochrome C Release CDC42 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOJ GTPase cycle RHOF GTPase cycle Transferrin endocytosis and recycling
Drugs
Diseases
GWAS		Cocaine dependence ( 23958962) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Renal cell carcinoma x sex interaction ( 31231134)
Interacting Genes		6 interacting genes: BAD BNIP3L MTDH PKMYT1 SETD7 TPT1
Entrez ID		55240
HPRD ID		10285
Ensembl ID		ENSG00000115107
Uniprot IDs		B8ZZX6 Q658P3
PDB IDs		2VNS 2VQ3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Mitochondrial Membrane Permeability Apoptotic Mitochondrial Changes Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Membrane Permeability Regulation Of Autophagy Negative Regulation Of Ectoderm Development Regulation Of Programmed Cell Death Regulation Of Cellular Response To Stress Regulation Of Apoptotic Process BAD-BCL-2 Complex Positive Regulation Of Catabolic Process Positive Regulation Of Type B Pancreatic Cell Development Mitochondrial Membrane Organization Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Negative Regulation Of G2/MI Transition Of Meiotic Cell Cycle Cellular Response To Oxygen Levels Regulation Of Intrinsic Apoptotic Signaling Pathway Peptidyl-lysine Dimethylation Positive Regulation Of Mitochondrial Membrane Potential Mitochondrial Outer Membrane Intercellular Canaliculus Regulation Of G2/MI Transition Of Meiotic Cell Cycle Negative Regulation Of Meiotic Cell Cycle Phase Transition Peptidyl-lysine Monomethylation Regulation Of Type B Pancreatic Cell Development Cellular Response To Nicotine Histone H3K4 Monomethyltransferase Activity Nucleolus Mitochondrial Outer Membrane Permeabilization Mitochondrion Organization Cysteine-type Endopeptidase Activator Activity Mitochondrial Protein Catabolic Process Positive Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Heterochromatin Organization Response To Hypoxia Regulation Of Cellular Response To Osmotic Stress Negative Regulation Of Membrane Potential Response To Decreased Oxygen Levels Regulation Of Response To Osmotic Stress Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Response To Oxygen Levels Lamin Binding Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death
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