GRIP2 and CSPG4

Number of citations of the paper that reports this interaction (PubMedID 12458226)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		GRIP2	CSPG4
Description		glutamate receptor interacting protein 2	chondroitin sulfate proteoglycan 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Glutamatergic Synapse	Ruffle Extracellular Region Nucleoplasm Golgi Lumen Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Extracellular Matrix Lamellipodium Membrane Cell Projection Lysosomal Lumen Extracellular Exosome
	Molecular Function		Coreceptor Activity Protein Kinase Binding
	Biological Process	Notch Signaling Pathway Artery Smooth Muscle Contraction Positive Regulation Of Blood Pressure Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse	Angiogenesis Substrate-dependent Cell Migration Signal Transduction Glial Cell Migration Cell Differentiation Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Platelet-derived Growth Factor Receptor Signaling Pathway Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Ruffle Assembly
Pathways		Trafficking of GluR2-containing AMPA receptors	Glycosaminoglycan-protein linkage region biosynthesis CS-GAG biosynthesis DS-GAG biosynthesis CS/DS degradation Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Defective B3GALT6 causes EDSP2 and SEMDJL1 Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Cognitive performance ( 19734545) Sjögren's syndrome ( 28076899)	Estimated glomerular filtration rate ( 31015462) Hip index ( 34021172) Intraocular pressure ( 29617998) Simvastatin-induced myopathy ( 31220337)
Interacting Genes		6 interacting genes: CSPG4 FMR1 FXR1 GFI1B GRIA2 GRIA3	9 interacting genes: ATF7IP BCAR1 C1QA CDC42 GRIP1 GRIP2 MPDZ PTK2 TNK2
Entrez ID		80852	1464
HPRD ID		18994	03105
Ensembl ID		ENSG00000144596	ENSG00000173546
Uniprot IDs		Q9C0E4	Q6UVK1
PDB IDs		1V62 1X5R	7ML7 7N8X 7N9Y
Enriched GO Terms of Interacting Partners?		Dendritic Spine Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Glutamate Receptor Signaling Pathway RNA Strand Annealing Activity AMPA Glutamate Receptor Activity Intracellular Membraneless Organelle Positive Regulation Of Long-term Neuronal Synaptic Plasticity Glutamate-gated Receptor Activity Positive Regulation Of MiRNA-mediated Gene Silencing Modulation Of Chemical Synaptic Transmission Translation Regulator Activity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Plasticity Regulation Of MiRNA-mediated Gene Silencing AMPA Glutamate Receptor Complex Regulation Of Post-transcriptional Gene Silencing Postsynapse Postsynaptic Membrane Ionotropic Glutamate Receptor Signaling Pathway Ligand-gated Monoatomic Ion Channel Activity Presynaptic Modulation Of Chemical Synaptic Transmission Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Synaptic Transmission, Glutamatergic Synapse Molecular Condensate Scaffold Activity Regulation Of Neuronal Synaptic Plasticity Endocytic Vesicle Membrane Regulation Of Membrane Potential Cytoplasmic Ribonucleoprotein Granule Positive Regulation Of Intracellular Transport Of Viral Material Dendrite Amyloid-beta Binding Cytoplasmic Stress Granule Regulation Of Postsynaptic Membrane Potential Postsynaptic Density Membrane Dendritic Filopodium Histone H3 Reader Activity MRNA Transport MRNA 3'-UTR Binding Negative Regulation Of Long-term Synaptic Depression Growth Cone Filopodium Positive Regulation Of Synaptic Transmission Ligand-gated Monoatomic Cation Channel Activity RNA Transport Positive Regulation Of Translation Monoatomic Ion Channel Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Communication	Endothelin Receptor Signaling Pathway Integrin-mediated Signaling Pathway Establishment Of Protein Localization To Postsynaptic Membrane Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Endosome To Plasma Membrane Protein Transport Neurotransmitter Receptor Transport Anchoring Junction Protein Localization To Postsynapse Protein Localization To Postsynaptic Membrane Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Localization To Synapse Establishment Of Protein Localization To Plasma Membrane Regulation Of Substrate Adhesion-dependent Cell Spreading Protein Localization To Synapse Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels ERBB Signaling Pathway Endocytic Recycling Protein Localization To Cell Junction Apical Part Of Cell Establishment Of Cell Polarity GBD Domain Binding Storage Vacuole Grb2-EGFR Complex Activation Of Immune Response Focal Adhesion Complement Component C1q Complex Vertebrate Eye-specific Patterning Cell Junction Organization Protein Kinase Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Dendrite Cytoophidium Cell Surface Receptor Signaling Pathway Extrinsic Component Of Presynaptic Membrane Complement-mediated Synapse Pruning Apolipoprotein A-I Receptor Binding Vesicle-mediated Transport Neuropilin Signaling Pathway Plasma Membrane Protein Tyrosine Kinase Activity Vesicle-mediated Transport To The Plasma Membrane IgM Binding
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