ACAD10 and NBR1

Number of citations of the paper that reports this interaction (PubMedID 36184612)
90

Data Source:
BioGRID (unspecified method)

		ACAD10	NBR1
Description		acyl-CoA dehydrogenase family member 10	NBR1 autophagy cargo receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Phagophore Assembly Site Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Intermembrane Space Lysosome Late Endosome Autophagosome Peroxisomal Membrane Cytosol Membrane Nuclear Body Cytoplasmic Vesicle M Band Receptor Complex Intracellular Organelle Lumen
	Molecular Function	Acyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Flavin Adenine Dinucleotide Binding	Protein Binding Zinc Ion Binding Ubiquitin Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Fatty Acid Beta-oxidation Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase	Macroautophagy Regulation Of Bone Mineralization Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Differentiation
Pathways		Mitochondrial Fatty Acid Beta-Oxidation	Pexophagy Pexophagy
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Body mass index ( 26426971) Coffee consumption ( 29367735) Colorectal cancer ( 26151821) Coronary artery disease ( 33020668) Coronary heart disease ( 23364394) Crohn's disease ( 28067908) Esophageal cancer ( 21642993) Estimated glomerular filtration rate ( 31015462) Fibrinogen levels ( 28107422) Fish consumption ( 32895509) Fish intake frequency ( 31320941) Inflammatory bowel disease ( 28067908) Myocardial infarction ( 30226566) Platelet count ( 22423221) Renal overload gout ( 32238385) Response to alcohol consumption (flushing response) ( 29460428) Serum alkaline phosphatase levels ( 33339817) Serum uric acid levels ( 32514006 29124443) Waist-to-hip ratio adjusted for BMI ( 34054925)
Interacting Genes		3 interacting genes: APP NBR1 SQSTM1	22 interacting genes: ACAD10 ATXN1L AXIN1 CALM1 CIB1 FEZ1 GABARAP GABARAPL2 GSK3A GSK3B ITSN2 MAP1LC3A MAP2K4 METAP1 SQSTM1 SYT4 TTN UBC UBE2D2 UBE2D3 USP8 VTA1
Entrez ID		80724	4077
HPRD ID		10625	01326
Ensembl ID		ENSG00000111271	ENSG00000188554
Uniprot IDs		Q6JQN1	B7Z5R6 Q14596
PDB IDs			1WJ6 2BKF 2CP8 2G4S 2L8J 2MGW 2MJ5 4OLE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Long-term Synaptic Potentiation Phagophore Assembly Site Lysosome Regulation Of Long-term Synaptic Potentiation Autophagosome Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cytoplasmic Vesicle Ubiquitin Binding Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Synaptic Plasticity Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Synaptic Transmission Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Receptor Complex Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Macroautophagy Late Endosome Brown Fat Cell Proliferation Amphisome Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Mitochondrion Autophagy Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Lewy Body Response To Mitochondrial Depolarisation Axon Choice Point Recognition	Ubiquitin Protein Ligase Binding Cellular Response To Nitrogen Starvation Beta-catenin Destruction Complex Regulation Of Protein Localization Catabolic Process Mitophagy Phosphatidylethanolamine Binding Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Macroautophagy Organelle Organization Autophagy Of Mitochondrion Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Autophagosome Regulation Of Protein Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Proteolysis Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Glycogen (starch) Synthase Activity Cytosol Regulation Of Post-translational Protein Modification Positive Regulation Of Proteasomal Protein Catabolic Process Extrinsic Apoptotic Signaling Pathway Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Proteolysis Involved In Protein Catabolic Process Organelle Assembly Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Sperm Midpiece Cellular Response To Interleukin-3 Autophagy Protein-containing Complex Disassembly Autophagosome Maturation Regulation Of Establishment Of Protein Localization Positive Regulation Of Establishment Of Protein Localization Regulation Of Type B Pancreatic Cell Development Autophagosome Membrane Apoptotic Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Vesicle Negative Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process
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