PBX4 and EIF3F

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PBX4	EIF3F
Description		PBX homeobox 4	eukaryotic translation initiation factor 3 subunit F
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleus	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Synapse Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Translation Initiation Factor Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Metallopeptidase Activity Hydrolase Activity Translation Initiation Factor Binding Identical Protein Binding Deubiquitinase Activity Metal-dependent Deubiquitinase Activity
	Biological Process	Eye Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Animal Organ Morphogenesis Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Neuron Development	Formation Of Cytoplasmic Translation Initiation Complex Cytoplasmic Translational Initiation Translation Translational Initiation Proteolysis IRES-dependent Viral Translational Initiation
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Quercetin
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 20686565) Cirrhosis (alcohol related) ( 32853455) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) LDL cholesterol ( 18193044 19060906 20686565) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 32888494 27863252) Obesity-related traits ( 23251661) Perceived unattractiveness to mosquitoes ( 28199695) Pulse pressure ( 27841878) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia ( 25056061 23974872 29483656) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Total cholesterol levels ( 30275531) Triglyceride levels (parental genotype effect) ( 30255771) Triglyceride levels in response to fenofibrate treatment (parental genotype effect) ( 30255771) Triglycerides ( 20686565 19060906 18193044)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depression (quantitative trait) ( 20800221) Malaria ( 31844061) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		63 interacting genes: AIRIM ARHGEF3 BCL6 BFSP2 C14orf119 CCM2L CDKN2C CFTR CHCHD2 CLCNKA CPNE7 EIF1AD EIF3B EIF3F EXOC8 GADD45GIP1 GEM GINS4 GPANK1 HOXB2 HOXB5 HOXC5 HOXC8 HOXD4 HSBP1L1 IFT20 IPO13 KDM1A KLHL38 LMO2 MAGOHB MAPK9 MBD3 MIPOL1 NCK2 NEK6 NUTF2 OSTF1 PACSIN2 PICK1 PIH1D2 PIK3R3 PPL RANBP3 RBX1 RIPPLY1 RIPPLY2 SCNM1 SERTAD1 SMARCD1 SPANXN2 SPANXN3 SPG21 TFIP11 TRIM41 TSEN15 TSSK3 TXNDC9 UBTFL1 USHBP1 USP20 WWOX ZNF330	47 interacting genes: AGR2 APP ATXN1 BTG3 C1orf216 CCDC120 CCDC196 CDC42 CDK11B CDK19 CDSN COL1A2 DKC1 EEF1A1 EIF3M EML2 ERCC6 FBXO32 HAX1 HGS HNRNPK HTR2A KLHL20 LCOR MCPH1 MKRN2 MSH4 MTOR MYDGF MYOZ1 NUP54 OGT PBX4 PKN1 POGZ POU6F2 PTN RABIF RIN1 RPS6KB1 RTP5 SHBG SMAD9 SUOX TEX56P TIMM10B WASHC1
Entrez ID		80714	8665
HPRD ID		16287	04887
Ensembl ID		ENSG00000105717	ENSG00000175390
Uniprot IDs		Q9BYU1	O00303
PDB IDs			3J8B 3J8C 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09 7QP6 7QP7 8OZ0 8PJ1 8PJ2 8PJ3 8PJ4 8PJ5 8PJ6 8PPL 8RG0 8XXN 9BLN
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Anterior/posterior Pattern Specification Skeletal System Morphogenesis	Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycolytic Process Negative Regulation Of TORC2 Signaling Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of ATP Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Nutrient Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Protein Localization Positive Regulation Of Translational Initiation Memory Positive Regulation Of RNA Biosynthetic Process Intracellular Signaling Cassette Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Positive Regulation Of DNA-templated Transcription Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Pseudopodium Assembly Skin Morphogenesis Regulation Of TORC2 Signaling Regulation Of Supramolecular Fiber Organization TORC2 Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Gliogenesis Positive Regulation Of TORC1 Signaling TORC1 Signaling Organelle Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Learning Protein Trimerization Positive Regulation Of Transcription By RNA Polymerase III Protein Tyrosine Kinase Activator Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process ATP-dependent DNA Damage Sensor Activity Regulation Of Insulin Receptor Signaling Pathway Regulation Of Gene Expression Response To Auditory Stimulus Mitochondrial Intermembrane Space
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