PBX4 and SPANXN3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PBX4	SPANXN3
Description		PBX homeobox 4	SPANX family member N3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin XY Body Nucleus
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Protein Binding
	Biological Process	Eye Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Animal Organ Morphogenesis Positive Regulation Of DNA-templated Transcription Embryonic Organ Development Neuron Development
Pathways
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder symptom score ( 27663945) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Cholesterol, total ( 20686565) Cirrhosis (alcohol related) ( 32853455) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) LDL cholesterol ( 18193044 19060906 20686565) LDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 32888494 27863252) Obesity-related traits ( 23251661) Perceived unattractiveness to mosquitoes ( 28199695) Pulse pressure ( 27841878) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Schizophrenia ( 25056061 23974872 29483656) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Total cholesterol levels ( 30275531) Triglyceride levels (parental genotype effect) ( 30255771) Triglyceride levels in response to fenofibrate treatment (parental genotype effect) ( 30255771) Triglycerides ( 20686565 19060906 18193044)	Creatine kinase levels ( 29403010)
Interacting Genes		63 interacting genes: AIRIM ARHGEF3 BCL6 BFSP2 C14orf119 CCM2L CDKN2C CFTR CHCHD2 CLCNKA CPNE7 EIF1AD EIF3B EIF3F EXOC8 GADD45GIP1 GEM GINS4 GPANK1 HOXB2 HOXB5 HOXC5 HOXC8 HOXD4 HSBP1L1 IFT20 IPO13 KDM1A KLHL38 LMO2 MAGOHB MAPK9 MBD3 MIPOL1 NCK2 NEK6 NUTF2 OSTF1 PACSIN2 PICK1 PIH1D2 PIK3R3 PPL RANBP3 RBX1 RIPPLY1 RIPPLY2 SCNM1 SERTAD1 SMARCD1 SPANXN2 SPANXN3 SPG21 TFIP11 TRIM41 TSEN15 TSSK3 TXNDC9 UBTFL1 USHBP1 USP20 WWOX ZNF330	17 interacting genes: APP ATP6V1C2 CAVIN1 CEP70 FAM217B FAM228A HAND2 MEOX2 NEDD4 PBX4 PTGES3L-AARSD1 SDCBP SP4 STAC3 YAF2 ZNF143 ZNF76
Entrez ID		80714	139067
HPRD ID		16287	18092
Ensembl ID		ENSG00000105717	ENSG00000189252
Uniprot IDs		Q9BYU1	Q5MJ09
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Nucleus Anterior/posterior Pattern Specification Skeletal System Morphogenesis	Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Amylin Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Frizzled Binding Positive Regulation Of DNA-templated Transcription Identical Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Formation Of Structure Involved In A Symbiotic Process Interleukin-5 Receptor Complex Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Semaphorin-plexin Signaling Pathway Positive Regulation Of RNA Metabolic Process Membrane Raft
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