ESX1 and TRAP1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ESX1	TRAP1
Description		ESX homeobox 1	TNF receptor associated protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Nuclear Speck	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane Intracellular Organelle Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein Kinase Binding Unfolded Protein Binding ATP-dependent Protein Folding Chaperone
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Neuron Development Regulation Of Cell Cycle	Protein Folding Translational Attenuation Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide
Pathways			Respiratory electron transport Citric acid cycle (TCA cycle)
Drugs
Diseases
GWAS			Asthma ( 32296059) Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist circumference adjusted for body mass index ( 34021172) White blood cell count ( 27863252 32888494)
Interacting Genes		2 interacting genes: EXOC2 TRAP1	17 interacting genes: APP ESX1 EXT1 EXT2 FXR1 HGS MCPH1 PSMC4 PTGER4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3
Entrez ID		80712	10131
HPRD ID		06503	05868
Ensembl ID		ENSG00000123576	ENSG00000126602
Uniprot IDs		Q8N693	A0A140VJY2 Q12931 Q53FS6
PDB IDs			4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O 6XG6 7C04 7C05 7C7B 7C7C 7KCK 7KCL 7KCM 7KLU 7KLV 7U8U 7U8V 7U8W 7U8X 7ULK
Enriched GO Terms of Interacting Partners?		Translational Attenuation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide Negative Regulation Of Cellular Respiration Protein Kinase Binding Regulation Of Entry Of Bacterium Into Host Cell Vesicle Tethering Involved In Exocytosis Intracellular Organelle Lumen Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Exocyst Tumor Necrosis Factor Receptor Binding ATP-dependent Protein Folding Chaperone Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Flemming Body Vesicle Docking Involved In Exocytosis Vesicle Tethering Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Membrane Fission Vesicle Docking Golgi To Plasma Membrane Transport Mitotic Cytokinesis Mitochondrial Intermembrane Space Organelle Localization By Membrane Tethering Cytoskeleton-dependent Cytokinesis Membrane Docking Post-Golgi Vesicle-mediated Transport Unfolded Protein Binding Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Vesicle-mediated Transport To The Plasma Membrane	Membrane Raft Receptor Complex Regulation Of Inflammatory Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Defense Response Negative Regulation Of Multicellular Organismal Process N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity Heparan Sulfate N-acetylglucosaminyltransferase Activity Regulation Of Extracellular Matrix Organization Cell Activation Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity Positive Regulation Of Extracellular Matrix Organization Transforming Growth Factor Beta Ligand-receptor Complex Microglial Cell Activation Activin Receptor Signaling Pathway Embryonic Cranial Skeleton Morphogenesis Mesenchymal Cell Differentiation Leukocyte Activation Involved In Inflammatory Response Regulation Of Signal Transduction Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Toll-like Receptor 2 Binding Detection Of Bacterial Lipoprotein Myeloid Leukocyte Activation Ventricular Septum Morphogenesis Chondrocyte Hypertrophy Animal Organ Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Gene Expression Endochondral Bone Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Multicellular Organismal Process Gastrulation SMAD Binding Protein Heterodimerization Activity Heparin Proteoglycan Biosynthetic Process Activin Receptor Complex Activin Receptor Activity, Type I Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Inflammatory Response Regulation Of Tumor Necrosis Factor Production Sebaceous Gland Development Transforming Growth Factor Beta Receptor Activity Lipopeptide Binding Developmental Process Chondrocyte Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition
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