ESX1 and EXOC2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ESX1	EXOC2
Gene Name		ESX homeobox 1	exocyst complex component 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Exocyst Cytosol Plasma Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding	Protein Binding Ral GTPase Binding Protein Kinase Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Labyrinthine Layer Morphogenesis Labyrinthine Layer Blood Vessel Development	Exocytosis Golgi To Plasma Membrane Transport Organelle Organization Protein Transport Cellular Protein Metabolic Process Membrane Organization
Pathways			Peptide hormone metabolism Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Translocation of GLUT4 to the plasma membrane VxPx cargo-targeting to cilium Assembly of the primary cilium Insulin processing
Drugs
Diseases
GWAS			Basal cell carcinoma ( 21700618) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Dental caries ( 23064961) Non-melanoma skin cancer ( 23548203) Schizophrenia ( 22885689) Tanning ( 19340012)
Protein-Protein Interactions		2 interactors: EXOC2 TRAP1	7 interactors: ESX1 EXOC3 EXOC7 EXOC8 RALA SERGEF VPS53
Entrez ID		80712	55770
HPRD ID		06503	11544
Ensembl ID		ENSG00000123576	ENSG00000112685
Uniprot IDs		Q8N693	B2RBE6 Q96KP1
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Respiration Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Golgi To Plasma Membrane Transport Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Response To Oxidative Stress Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Post-Golgi Vesicle-mediated Transport Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process	Exocyst Localization Exocytosis Secretion By Cell Cellular Protein Complex Localization Protein Complex Localization Vesicle-mediated Transport Secretion Membrane Organization Establishment Of Localization In Cell Cellular Localization Exocyst Assembly Protein Transport Establishment Of Protein Localization Membrane Raft Localization Protein Localization Positive Regulation Of Ran GTPase Activity Transport Labyrinthine Layer Morphogenesis
Tagcloud ?		apparatus assembled assembly colocalize conservation deletions determinant establishment exploit fluorescently fluoro governing illustrates lapse localization localize msesx1 mtbesx mtbesx1 mycobacterium pathogenicity polar pole remarkably septal smegmatis tagged virulence	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?		apparatus assembled assembly colocalize conservation deletions determinant establishment exploit fluorescently fluoro governing illustrates lapse localization localize msesx1 mtbesx mtbesx1 mycobacterium pathogenicity polar pole remarkably septal smegmatis tagged virulence	agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacb prkacg prkar1a prkar2a prkar2b proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?