RHOBTB2 and PPM1D

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		RHOBTB2	PPM1D
Description		Rho related BTB domain containing 2	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image		No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Plasma Membrane Endosome Membrane Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Cell Projection	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Serine/threonine Kinase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Cell Shape Protein Ubiquitination Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization	G2/M Transition Of Mitotic Cell Cycle DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Intracellular Signal Transduction
Pathways		RHOBTB2 GTPase cycle	Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Aspartate aminotransferase levels ( 33547301) Basal cell carcinoma ( 33549134) Height ( 28552196) Plasma trimethylamine N-oxide levels ( 28439531) Renal cell carcinoma ( 28598434) Survival in breast cancer (estrogen-receptor positive) ( 29423119)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		12 interacting genes: BAG4 CHEK2 CUL5 ERBB2 FGFR2 HSP90AA1 HSP90AB1 PALB2 PPM1D PTPN1 RHOBTB3 STK11	25 interacting genes: BEX2 CASZ1 CDKN1A CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		23221	8493
HPRD ID		06300	05482
Ensembl ID		ENSG00000008853	ENSG00000170836
Uniprot IDs		Q9BYZ6	A0A0S2Z4M2 O15297
PDB IDs			8T2J
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Binding Cellular Response To Stress Response To Stress ATP Binding Regulation Of Intracellular Signal Transduction Macromolecule Metabolic Process Nitric-oxide Synthase Regulator Activity Dendritic Growth Cone TPR Domain Binding Telomerase Holoenzyme Complex Assembly Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Protein Localization Protein Metabolic Process Protein Stabilization Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Response To Unfolded Protein Protein Dephosphorylation Cellular Response To Growth Factor Stimulus Protein Modification Process Signal Transduction By P53 Class Mediator Regulation Of Protein Modification Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Nucleotide Binding Response To Growth Factor Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Protein Autophosphorylation Negative Regulation Of Cell Population Proliferation Dephosphorylation Chaperone-mediated Protein Complex Assembly Telomere Maintenance Via Telomerase Regulation Of Protein Stability DNA Polymerase Binding Phosphorylation ERBB2 Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Axonal Growth Cone RNA-templated DNA Biosynthetic Process Mitotic Cell Cycle Phase Transition Phosphate-containing Compound Metabolic Process MHC Class II Protein Complex Binding Disordered Domain Specific Binding Cell Cycle Phase Transition Negative Regulation Of Apoptotic Process Myelin Sheath Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Cellular Response To Gamma Radiation Response To Gamma Radiation Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Radiation Cellular Response To Light Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Response To Ionizing Radiation Response To UV Ubiquitin Protein Ligase Binding Cellular Response To Actinomycin D Response To Actinomycin D Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To UV-C Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Catalytic Activity Cellular Response To Antibiotic 5S RRNA Binding Protein-containing Complex Response To Light Stimulus Cellular Senescence Thymocyte Apoptotic Process Mitotic DNA Damage Checkpoint Signaling P53 Binding Mitotic DNA Integrity Checkpoint Signaling Cellular Response To UV-B Response To UV-C Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Protein Modification Process Negative Regulation Of Growth Chromatin Remodeling DNA Damage Checkpoint Signaling Response To UV-B Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA 5'-UTR Binding
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