FSTL3 and MSTN

Number of citations of the paper that reports this interaction (PMID 12194980)
79

Data Source:
HPRD (in vitro, in vivo)

		FSTL3	MSTN
Gene Name		follistatin-like 3 (secreted glycoprotein)	myostatin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Golgi Apparatus Secretory Granule Neuron Projection Terminus	Extracellular Space Cytoplasm
	Molecular Function	Fibronectin Binding Protein Binding Activin Binding	Receptor Binding Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Identical Protein Binding
	Biological Process	Ossification Kidney Development Hematopoietic Progenitor Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spermatogenesis Male Gonad Development Positive Regulation Of Cell-cell Adhesion Lung Development Adrenal Gland Development Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Metal Ion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Transforming Growth Factor Beta Receptor Signaling Pathway Muscle Organ Development Response To Heat Response To Gravity Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Skeletal Muscle Atrophy Negative Regulation Of Muscle Hypertrophy Response To Muscle Activity Ovulation Cycle Process Response To Testosterone Regulation Of Apoptotic Process Skeletal Muscle Tissue Regeneration Regulation Of MAPK Cascade Response To Estrogen Response To Ethanol Positive Regulation Of Transcription, DNA-templated Cell Development Negative Regulation Of Skeletal Muscle Tissue Growth Response To Electrical Stimulus SMAD Protein Signal Transduction Cellular Response To Dexamethasone Stimulus Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Myoblast Proliferation
Pathways		Antagonism of Activin by Follistatin Signaling by Activin
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ADAM12 FN1 INHBA MSTN SMAD4	6 interactors: ACVR2B APP FSTL3 SGTA TCAP WFIKKN2
Entrez ID		10272	2660
HPRD ID		05632	03474
Ensembl ID		ENSG00000070404	ENSG00000138379
Uniprot IDs		O95633	O14793 Q53S46
PDB IDs		2KCX 3B4V 3SEK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Endoderm Development Regulation Of Growth Gastrulation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Endodermal Cell Differentiation Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Endoderm Formation Cell Differentiation Growth Regulation Of Cell Differentiation Tissue Development Cell Development Ovulation Cycle Process Embryonic Morphogenesis Palate Development Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Myoblast Proliferation Negative Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Ovulation Cycle Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Differentiation Formation Of Primary Germ Layer Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mesoderm Development Anatomical Structure Development Progesterone Secretion Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Cell Growth Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Response To Transforming Growth Factor Beta	Regulation Of Activin Receptor Signaling Pathway Muscle Fiber Development Palate Development Cell Differentiation Synaptic Growth At Neuromuscular Junction Regulation Of Protein Binding Striated Muscle Cell Development Sarcomerogenesis Collateral Sprouting In Absence Of Injury Detection Of Muscle Stretch Skeletal Muscle Myosin Thick Filament Assembly Muscle Cell Development System Development Collateral Sprouting Axon Midline Choice Point Recognition Myosin Filament Assembly Striated Muscle Cell Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Multicellular Organismal Development Axon Choice Point Recognition Skeletal Muscle Thin Filament Assembly Lung Development Anterior/posterior Pattern Specification Respiratory Tube Development Regulation Of Binding Negative Regulation Of Endopeptidase Activity Positive Regulation Of Activin Receptor Signaling Pathway Anatomical Structure Development Negative Regulation Of Peptidase Activity Cardiac Muscle Fiber Development Response To Muscle Stretch Skeletal Myofibril Assembly Lymphatic Endothelial Cell Differentiation Respiratory System Development Neuron Remodeling Negative Regulation Of Activin Receptor Signaling Pathway Kidney Development Muscle Cell Differentiation Otic Vesicle Formation Renal System Development Lymphangiogenesis Organ Development Negative Regulation Of Proteolysis Otic Vesicle Morphogenesis Developmental Process Lymph Vessel Morphogenesis Negative Regulation Of Protein Processing Urogenital System Development Regulation Of Endopeptidase Activity
Tagcloud ?			adenoviral adenovirus aforesaid backgrounds conversion decades ectopic electroporation eliminating facilitated fibroblasts fos lentiviral master muscle muscles myoblasts myod myogenesis myogenic myostatin myotubes negligible offers scarcity take transduced transducing wasting
Tagcloud (Difference) ?			adenoviral adenovirus aforesaid backgrounds conversion decades ectopic electroporation eliminating facilitated fibroblasts fos lentiviral master muscle muscles myoblasts myod myogenesis myogenic myostatin myotubes negligible offers scarcity take transduced transducing wasting
Tagcloud (Intersection) ?