FSTL3 and ADAM12

Number of citations of the paper that reports this interaction (PMID 15574124)
5

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		FSTL3	ADAM12
Gene Name		follistatin-like 3 (secreted glycoprotein)	ADAM metallopeptidase domain 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Golgi Apparatus Secretory Granule Neuron Projection Terminus	Extracellular Region Nucleoplasm Mitochondrion Plasma Membrane Integral Component Of Membrane
	Molecular Function	Fibronectin Binding Protein Binding Activin Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding SH3 Domain Binding
	Biological Process	Ossification Kidney Development Hematopoietic Progenitor Cell Differentiation Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Spermatogenesis Male Gonad Development Positive Regulation Of Cell-cell Adhesion Lung Development Adrenal Gland Development Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Metal Ion Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Proteolysis Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway Myoblast Fusion
Pathways		Antagonism of Activin by Follistatin Signaling by Activin	Signaling by EGFR Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS			Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Protein-Protein Interactions		5 interactors: ADAM12 FN1 INHBA MSTN SMAD4	11 interactors: ACTN2 EGF FSTL3 GRB2 IGFBP3 IGFBP5 PACSIN3 PIK3R1 SH3D19 SRC YES1
Entrez ID		10272	8038
HPRD ID		05632	04092
Ensembl ID		ENSG00000070404	ENSG00000148848
Uniprot IDs		O95633	A8K6G4 O43184
PDB IDs		2KCX 3B4V 3SEK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Endoderm Development Regulation Of Growth Gastrulation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cellular Protein Metabolic Process Endodermal Cell Differentiation Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Endoderm Formation Cell Differentiation Growth Regulation Of Cell Differentiation Tissue Development Cell Development Ovulation Cycle Process Embryonic Morphogenesis Palate Development Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Myoblast Proliferation Negative Regulation Of Skeletal Muscle Tissue Growth Negative Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Ovulation Cycle Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Differentiation Formation Of Primary Germ Layer Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Metabolic Process Mesoderm Development Anatomical Structure Development Progesterone Secretion Nephrogenic Mesenchyme Morphogenesis Negative Regulation Of Satellite Cell Differentiation Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Negative Regulation Of Cell Growth Positive Regulation Of Cell Differentiation Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Phosphorylation Anatomical Structure Morphogenesis Positive Regulation Of Protein Modification Process Cellular Response To Transforming Growth Factor Beta Stimulus Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Response To Transforming Growth Factor Beta	Blood Coagulation Hemostasis Platelet Activation Vesicle-mediated Transport T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Fc Receptor Signaling Pathway Regulation Of Body Fluid Levels Wound Healing Regulation Of Cellular Component Organization Response To Wounding Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Carbohydrate Metabolic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Smooth Muscle Cell Migration Immune Response-regulating Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Organonitrogen Compound Response To Fibroblast Growth Factor Positive Regulation Of T Cell Activation Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Metabolic Process Neurotrophin Signaling Pathway Leukocyte Migration Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signal Transduction Phagocytosis Regulation Of Cell Adhesion Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Cell Activation Positive Regulation Of Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Regulation Of Immune System Process Cellular Response To Peptide
Tagcloud ?			alpha1 anchoring balanced brdu cct ccts cytotrophoblasts eclampsia evt evts exaggerated explant extravillous fibronectin floating hes1 labelling maml notch outgrowth overgrowth placental rbpjkappa sirnas trimester trophoblast trophoblasts villi villous
Tagcloud (Difference) ?			alpha1 anchoring balanced brdu cct ccts cytotrophoblasts eclampsia evt evts exaggerated explant extravillous fibronectin floating hes1 labelling maml notch outgrowth overgrowth placental rbpjkappa sirnas trimester trophoblast trophoblasts villi villous
Tagcloud (Intersection) ?