FSTL3 and INHBA

Number of citations of the paper that reports this interaction (PubMedID 11459787)
0

Data Source:
HPRD (in vitro)

		FSTL3	INHBA
Description		follistatin like 3	inhibin subunit beta A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Activin A Complex Inhibin A Complex Perinuclear Region Of Cytoplasm Enzyme Activator Complex
	Molecular Function	Fibronectin Binding Protein Binding Activin Binding	Signaling Receptor Binding Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Peptide Hormone Binding Identical Protein Binding Protein-containing Complex Binding Type II Activin Receptor Binding
	Biological Process	Ossification Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-cell Adhesion Cell Differentiation Regulation Of BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Ovarian Follicle Development Mesoderm Formation Hair Follicle Development Hematopoietic Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Lipid Metabolic Process Steroid Biosynthetic Process Autophagy Defense Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-cell Signaling Nervous System Development Steroid Metabolic Process Androgen Metabolic Process Negative Regulation Of Cell Population Proliferation Male Gonad Development Response To Wounding Gene Expression Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Striatal Medium Spiny Neuron Differentiation Cell Differentiation Erythrocyte Differentiation Negative Regulation Of Cell Growth Negative Regulation Of Type II Interferon Production Activin Receptor Signaling Pathway Positive Regulation Of Collagen Biosynthetic Process Endodermal Cell Differentiation Negative Regulation Of Phosphorylation Odontogenesis Hemoglobin Biosynthetic Process Progesterone Secretion Negative Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Mesodermal Cell Differentiation Cell Development Animal Organ Development System Development Positive Regulation Of Protein Metabolic Process Sertoli Cell Differentiation Roof Of Mouth Development Positive Regulation Of Ovulation Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Cardiac Fibroblast Cell Development Eyelid Development In Camera-type Eye Testosterone Biosynthetic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Cellular Response To Hypoxia Cellular Response To Oxygen-glucose Deprivation GABAergic Neuron Differentiation Extrinsic Apoptotic Signaling Pathway Androst-4-ene-3,17-dione Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Antagonism of Activin by Follistatin Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Signaling by Activin Signaling by Activin Signaling by BMP Glycoprotein hormones Antagonism of Activin by Follistatin TGFBR3 regulates activin signaling
Drugs			Garetosmab
Diseases
GWAS		Nickel levels ( 26025379)	Asthma ( 29273806) Cortisol levels (saliva) ( 28843169) Menarche (age at onset) ( 21102462 25231870 27182965) Parent of origin effect on language impairment (paternal) ( 24571439) Pit-and-Fissure caries ( 23470693)
Interacting Genes		5 interacting genes: ADAM12 FN1 INHBA MSTN SMAD4	15 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B BMPR2 CFTR CHRDL2 ENG FST FSTL3 IGFBP7 INHA INHBB INHBC TGFBR3
Entrez ID		10272	3624
HPRD ID		05632	00929
Ensembl ID		ENSG00000070404	ENSG00000122641
Uniprot IDs		O95633	A4D1W7 P08476
PDB IDs		2KCX 3B4V 3SEK	1NYS 1NYU 1S4Y 2ARP 2ARV 2B0U 2P6A 3B4V 4MID 5HLY 5HLZ 6Y6N 6Y6O 7OLY 7U5P 9I5W
Enriched GO Terms of Interacting Partners?		Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Ameboidal-type Cell Migration Regulation Of Growth Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Growth SMAD Protein Signal Transduction Anatomical Structure Formation Involved In Morphogenesis Response To Muscle Activity Activin Receptor Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Endodermal Cell Differentiation Regulation Of Developmental Process Ovulation Cycle Process Negative Regulation Of Muscle Hypertrophy Response To Hypoxia Response To Decreased Oxygen Levels Positive Regulation Of SMAD Protein Signal Transduction Response To Oxygen Levels Ovarian Follicle Development Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Growth Signaling Receptor Binding Collagen Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Regulation Of SMAD Protein Signal Transduction Regulation Of Multicellular Organismal Development Response To Activity Animal Organ Development Roof Of Mouth Development Activin A Complex Androst-4-ene-3,17-dione Biosynthetic Process Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Regulation Of Cell Differentiation Regulation Of System Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Male Gonad Development Extrinsic Apoptotic Signaling Pathway Regulation Of MAPK Cascade Identical Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Cell Differentiation Negative Regulation Of Skeletal Muscle Tissue Growth	Activin Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Activin Receptor Signaling Pathway Activin Receptor Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity BMP Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Growth Factor Binding Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Complex Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Development Positive Regulation Of SMAD Protein Signal Transduction Inhibin-betaglycan-ActRII Complex Activin Receptor Activity, Type II Positive Regulation Of Biomineral Tissue Development Inhibin Binding Activin Receptor Activity BMP Binding Positive Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Growth Factor Regulation Of Developmental Process Positive Regulation Of Activin Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Receptor Complex Activin Receptor Activity, Type I BMP Receptor Activity Positive Regulation Of Multicellular Organismal Process Cell Surface Positive Regulation Of Bone Mineralization Regulation Of Ossification Regulation Of Multicellular Organismal Process Animal Organ Development Positive Regulation Of Ossification Extracellular Space Coreceptor Activity Regulation Of Cell Differentiation Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Odontogenesis Of Dentin-containing Tooth
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?