KLHL15 and RBBP8

Number of citations of the paper that reports this interaction (PubMedID 35219381)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)

		KLHL15	RBBP8
Description		kelch like family member 15	RB binding protein 8, endonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Chromosome Transcription Repressor Complex Site Of Double-strand Break BRCA1-C Complex
	Molecular Function	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Damaged DNA Binding Transcription Corepressor Activity Nuclease Activity Endonuclease Activity Protein Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Blastocyst Hatching DNA Repair DNA Damage Response DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Homologous Recombination Mitotic G2/M Transition Checkpoint Negative Regulation Of DNA-templated Transcription Cell Division Meiotic Cell Cycle DNA Strand Resection Involved In Replication Fork Processing
Pathways			HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			Seckel syndrome
GWAS		Prostate-specific antigen levels ( 28139693)	Eosinophil percentage of white cells ( 27863252) Estradiol levels ( 34255042) Height ( 18391951 25429064) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte count ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		3 interacting genes: MARCHF6-DT PPP2R2B RBBP8	40 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PAN2 PCNA PELI2 PIAS4 PIN1 PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 RNF4 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 UBE2I USP4
Entrez ID		80311	5932
HPRD ID		09957	04990
Ensembl ID		ENSG00000174010	ENSG00000101773
Uniprot IDs		Q96M94 V9HWF1	Q99708
PDB IDs			1Y98 2L4Z 4D2H 7BGF
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Mitotic DNA Replication Initiation Lagging Strand Elongation Alpha DNA Polymerase:primase Complex DNA Synthesis Involved In UV-damage Excision Repair Leading Strand Elongation DNA Replication, Synthesis Of Primer BRCA1-C Complex DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Poly-ADP-D-ribose Binding Regulation Of Protein ADP-ribosylation Single-stranded DNA Endodeoxyribonuclease Activity DNA Strand Elongation Involved In DNA Replication DNA Polymerase Activity DNA Replication Origin Binding Protein Phosphatase Type 2A Complex DNA Strand Resection Involved In Replication Fork Processing DNA Strand Elongation DNA Repair DNA-directed DNA Polymerase Activity DNA Replication Initiation Blastocyst Hatching DNA Double-strand Break Processing	Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Post-translational Protein Modification Protein Modification By Small Protein Conjugation Positive Regulation Of Metabolic Process Protein Modification Process BRCA1-B Complex Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Mitotic G2/M Transition Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Mitotic Cell Cycle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Protein Ubiquitination Mitotic G2 DNA Damage Checkpoint Signaling Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Metabolic Process Homologous Recombination Nucleoplasm Regulation Of Apoptotic Signaling Pathway Protein Polyubiquitination DNA Strand Resection Involved In Replication Fork Processing
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