NCOA4 and ATXN2

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NCOA4	ATXN2
Description		nuclear receptor coactivator 4	ataxin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Lysosome Autophagosome Cytoplasmic Vesicle Autolysosome	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Cytoplasmic Stress Granule Membrane Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding	RNA Binding MRNA Binding Epidermal Growth Factor Receptor Binding Protein Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Iron Ion Homeostasis Male Gonad Development Response To Hormone Estrogen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Cellular Response To Estrogen Stimulus Cellular Response To Testosterone Stimulus	Negative Regulation Of Receptor Internalization Regulation Of Translation RNA Metabolic Process P-body Assembly Stress Granule Assembly RNA Transport
Pathways		MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases		Thyroid cancer	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular volume ( 20139978 29403010) Red blood cell count ( 29403010)	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Alopecia areata ( 25608926) Apolipoprotein B levels ( 32203549) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 30929738 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Beta-2 microglubulin plasma levels ( 23417110) Blood osmolality (transformed sodium) ( 28360221) Blood pressure ( 21909110) Body mass index ( 26426971) Body mass index and coronary artery disease (pairwise) ( 33619380) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index and systole blood pressure (pairwise) ( 33619380) Caffeine consumption from coffee or tea ( 33287642) Celiac disease ( 18311140 22057235) Chronic kidney disease ( 20383146) Coronary artery disease ( 29212778) Crohn's disease ( 26192919 28067908) Diastolic blood pressure ( 19430483 26390057 27736895) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Estimated glomerular filtration rate ( 31015462 31152163) Gastroesophageal reflux disease ( 31527586) Glaucoma (primary open-angle) ( 26752265 33627673) Glomerular filtration rate (cystatin C) ( 28452372) Glycated hemoglobin levels ( 28898252) HDL cholesterol ( 30275531) Heart failure ( 31919418) Hematocrit ( 19862010) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 31879980) Hypothyroidism ( 22493691 27182965) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 26192919 28067908) Intraocular pressure ( 30054594) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Left ventricle diastolic internal dimension ( 28394258) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Myeloproliferative neoplasms ( 33057200) Myocardial infarction ( 30226566 33532862) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Parental lifespan ( 30642433) Parental longevity (combined parental age at death) ( 29227965) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965) Parental longevity (father's age at death) ( 29227965) Parental longevity (father's attained age) ( 29227965) Parental longevity (mother's attained age) ( 29227965) Peripheral artery disease ( 25009551) Platelet count ( 24026423 27863252 29403010 32888494 33545615) Platelet distribution width ( 27863252) Plateletcrit ( 27863252 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 23603763) Reaction time ( 29844566) Red blood cell count ( 32888494) Red blood cell traits ( 23222517) Reticulocyte fraction of red cells ( 27863252) Retinal vascular caliber ( 21060863) Sarcoidosis ( 26051272) Serum alkaline phosphatase levels ( 33547301) Serum total protein levels ( 29403010) Sjögren's syndrome ( 24097067) Smoking initiation ( 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469 33272962) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24586183) Total cholesterol levels ( 30275531) Urate levels ( 23263486 31578528) Vitiligo ( 27723757) White blood cell count ( 32888494)
Interacting Genes		12 interacting genes: AKT1 AR ATXN2 ESR1 GTF2B KAT2B MID2 NR3C1 PPARG RNF14 RXRA VDR	23 interacting genes: ACTN1 ACTN2 ATXN1 BAG6 BIN1 CEBPA CHGB GFI1B GOLGA6L5P IDH3B KIFBP LCP1 MIR128-1 MIR34B MIR7-1 NCOA4 PABPC1 PLS3 POLR1H RBFOX1 SH3GL2 SH3GL3 TDRD7
Entrez ID		8031	6311
HPRD ID		03584	03307
Ensembl ID		ENSG00000266412	ENSG00000204842
Uniprot IDs		B2R5V0 Q13772 Q96E88	A0A5F9ZI57 F8VQP2 Q2M2R5 Q99700 V9GY86
PDB IDs		1T5Z 8QU9	3KTR
Enriched GO Terms of Interacting Partners?		Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Nuclear Receptor Activity Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Steroid Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Estrogen Response Element Binding Cellular Response To Hormone Stimulus Enzyme Binding Regulation Of MiRNA Transcription DNA-templated Transcription Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipid Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process Zinc Ion Binding Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process TBP-class Protein Binding Negative Regulation Of RNA Metabolic Process Steroid Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Maternal Process Involved In Female Pregnancy Vitamin D Response Element Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Hormone RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Chromatin Cellular Response To Lipoprotein Particle Stimulus DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Pregnancy DNA Binding Domain Binding Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II	Actin Filament Network Formation Actin Filament Binding Actin Filament Actin Filament Bundle Organization Actin Cytoskeleton Organization Actin Filament Bundle Assembly Actin Filament Bundle Regulatory NcRNA-mediated Gene Silencing Actin Filament-based Process Cytoskeleton Organization Pseudopodium Negative Regulation Of Transport Postsynaptic Density, Intracellular Component Postsynaptic Actin Cytoskeleton Organization Identical Protein Binding Postsynaptic Cytoskeleton Organization Poly(U) RNA Binding Positive Regulation Of RNA Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of MRNA Catabolic Process Actin Cytoskeleton Organelle Organization Focal Adhesion Assembly Positive Regulation Of Nucleobase-containing Compound Metabolic Process Integrin Binding Glutamatergic Synapse Regulation Of Gene Expression Z Disc Cell-substrate Junction Assembly Regulation Of Transport Negative Regulation Of Potassium Ion Transport Actin Filament Uncapping Regulation Of Vesicle-mediated Transport GTPase Binding Synaptic Vesicle Endocytosis Lipid Tube Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential Nuclear Matrix Positive Regulation Of Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Structural Constituent Of Presynaptic Actin Cytoskeleton Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process MRNA 3'-UTR Binding Positive Regulation Of MRNA Metabolic Process Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Negative Regulation Of Lipoprotein Transport MiRNA-mediated Gene Silencing By MRNA Destabilization
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