NCOA4

Description		nuclear receptor coactivator 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Lysosome Autophagosome Cytoplasmic Vesicle Autolysosome
	Molecular Function	Transcription Coactivator Activity Protein Binding
	Biological Process	Protein Targeting To Lysosome Intracellular Iron Ion Homeostasis Male Gonad Development Response To Hormone Estrogen Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Cellular Response To Estrogen Stimulus Cellular Response To Testosterone Stimulus
Pathways		MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases		Thyroid cancer
GWAS		Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) levels in Hashimoto's thyroiditis ( 30926877) Apolipoprotein A1 levels ( 32203549) Mean corpuscular hemoglobin ( 20139978 29403010) Mean corpuscular volume ( 20139978 29403010) Red blood cell count ( 29403010)
Interacting Genes		12 interacting genes: AKT1 AR ATXN2 ESR1 GTF2B KAT2B MID2 NR3C1 PPARG RNF14 RXRA VDR
Entrez ID		8031
HPRD ID		03584
Ensembl ID		ENSG00000266412
Uniprot IDs		B2R5V0 Q13772 Q96E88
PDB IDs		1T5Z 8QU9
Enriched GO Terms of Interacting Partners?		Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Nuclear Receptor Activity Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Steroid Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Estrogen Response Element Binding Cellular Response To Hormone Stimulus Enzyme Binding Regulation Of MiRNA Transcription DNA-templated Transcription Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Lipid Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process Zinc Ion Binding Retinoic Acid Receptor Signaling Pathway RNA Metabolic Process TBP-class Protein Binding Negative Regulation Of RNA Metabolic Process Steroid Binding Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Maternal Process Involved In Female Pregnancy Vitamin D Response Element Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Lipid Metabolic Process Response To Hormone RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Lipid Metabolic Process Chromatin Cellular Response To Lipoprotein Particle Stimulus DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Pregnancy DNA Binding Domain Binding Transcription Coregulator Binding Regulation Of Transcription By RNA Polymerase II
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