CDK5RAP3 and DGCR14

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDK5RAP3	DGCR14
Gene Name		CDK5 regulatory subunit associated protein 3	DiGeorge syndrome critical region gene 14
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane Protein Complex	Nucleus Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Protein Kinase Binding	Molecular_function Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Brain Development Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Ufmylation	MRNA Splicing, Via Spliceosome Nervous System Development
Pathways
Drugs
Diseases
GWAS		Epilepsy (generalized) ( 22949513)
Protein-Protein Interactions		11 interactors: CDK5R1 CREBBP CRMP1 DGCR14 DISC1 FKBP6 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4	11 interactors: CDK5RAP3 CRP DHX16 FRA10AC1 GNB2L1 LYST PFDN1 RBM4 TTC14 VIM WNK2
Entrez ID		80279	8220
HPRD ID		12190	03452
Ensembl ID		ENSG00000108465	ENSG00000100056
Uniprot IDs		B7Z6N4 F5H3I5 Q96JB5	Q96DF8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cerebral Cortex Radially Oriented Cell Migration Positive Regulation Of Protein Modification Process Cerebral Cortex Cell Migration Superior Olivary Nucleus Maturation Telencephalon Cell Migration Forebrain Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Pons Maturation N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Serine Phosphorylation Of STAT3 Protein Cerebral Cortex Development Germ-line Stem Cell Maintenance Serine Phosphorylation Of STAT Protein Neuron Migration Signal Transduction Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Localization To Cell Surface Activation Of MAPKKK Activity Pallium Development Regulation Of Protein Kinase Activity	Negative Regulation Of Translation Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Positive Regulation Of CAMP Catabolic Process Mast Cell Secretory Granule Organization Regulation Of Neuron Differentiation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Ion Homeostasis Regulation Of Cell Differentiation IRES-dependent Translational Initiation Cap-independent Translational Initiation Regulation Of Neurogenesis Endosome Transport Via Multivesicular Body Sorting Pathway Circadian Regulation Of Translation Defense Response To Bacterium Negative Regulation Of Oxidative Stress-induced Neuron Death Bergmann Glial Cell Differentiation Negative Regulation Of Vasodilation Secretion Of Lysosomal Enzymes Protein Ufmylation Negative Regulation Of Translation In Response To Stress Regulation Of Cell Development Negative Regulation Of Translation Involved In Gene Silencing By MiRNA Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Homooligomerization Positive Regulation Of Gastrulation Phospholipid Homeostasis Regulation Of Gene Expression Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cytoplasmic Translational Initiation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Mitochondrial Depolarization Opsonization Leukocyte Mediated Immunity Adaptive Immune Response Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Phagocytosis Regulation Of Translation Cell Differentiation Central Nervous System Development Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Superoxide Anion Generation Regulation Of Interleukin-8 Secretion Regulation Of Cellular Localization Rhythmic Process Regulation Of Metabolic Process Cytoplasmic Translation Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Translation In Response To Stress Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Tagcloud ?		anchors aspartate ataxin atx1 autonomous bergmann cerebellum collectively consistently downregulated eventually glia glutamate helix interacting knockin maxer mediates mediating mutant named purkinje represses repression rescues sca1 strengthened transporter vulnerability
Tagcloud (Difference) ?		anchors aspartate ataxin atx1 autonomous bergmann cerebellum collectively consistently downregulated eventually glia glutamate helix interacting knockin maxer mediates mediating mutant named purkinje represses repression rescues sca1 strengthened transporter vulnerability
Tagcloud (Intersection) ?