CDK5RAP3 and ESS2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CDK5RAP3	ESS2
Description		CDK5 regulatory subunit associated protein 3	ess-2 spliceosome associated protein
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Protein-containing Complex	Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Protein Kinase Binding Cyclin Binding Ubiquitin-like Protein Ligase Binding Mitogen-activated Protein Kinase Binding NF-kappaB Binding MDM2/MDM4 Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Liver Development Negative Regulation Of Protein Phosphorylation Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Brain Development Blood Circulation Cell Population Proliferation Regulation Of Phosphatase Activity Apoptotic Nuclear Changes Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Ribosome Disassembly Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Mitotic G2/M Transition Checkpoint Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Definitive Erythrocyte Differentiation Protein Ufmylation Negative Regulation Of Protein Serine/threonine Kinase Activity Rescue Of Stalled Ribosome Positive Regulation Of Reticulophagy Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Generalized epilepsy ( 22949513) Metabolite levels (Pyroglutamine) ( 23934736)
Interacting Genes		13 interacting genes: CDK5R1 CREBBP CRMP1 DISC1 ESS2 FKBP6 HSPB1 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4 VHL	33 interacting genes: ARMC7 CCDC57 CDK5RAP3 CEP55 CPSF7 CRP DGCR6 DHX16 EHMT2 EXOC8 EXOSC7 HOOK1 ITCH KRT31 LYST NEDD4 OGT OIP5 PFDN1 PRPF38B PRRC2B QARS1 RACK1 RBM22 RBM4 SMARCD1 THOC1 TRAK1 TTC14 UTP6 VIM WNK2 YAP1
Entrez ID		80279	8220
HPRD ID		12190	03452
Ensembl ID		ENSG00000108465	ENSG00000100056
Uniprot IDs		Q96JB5	F8WEF8 Q96DF8
PDB IDs		8OHD 8OJ0 8OJ5 8QFC	8C6J 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		Contractile Muscle Fiber Cell Surface Receptor Signaling Pathway Regulation Of Postsynapse Organization Non-canonical NF-kappaB Signal Transduction Cerebral Cortex Cell Migration Cerebral Cortex Radially Oriented Cell Migration Molecular Adaptor Activity Telencephalon Cell Migration Forebrain Cell Migration	RNA Metabolic Process Cyclin Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing Lysosomal Transport Positive Regulation Of Stem Cell Population Maintenance Endosome To Lysosome Transport Vacuolar Transport Negative Regulation Of MAPK Cascade RNA Binding Regulation Of Stem Cell Population Maintenance Spliceosomal Complex Molecular Adaptor Activity Proline-rich Region Binding Regulation Of Macroautophagy Pre-mRNA Binding
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