CDK5RAP3 and SRPRB

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		CDK5RAP3	SRPRB
Gene Name		CDK5 regulatory subunit associated protein 3	signal recognition particle receptor, B subunit
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane Protein Complex	Cytoplasm Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Protein Kinase Binding	GTP Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Brain Development Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Ufmylation	Translation SRP-dependent Cotranslational Protein Targeting To Membrane Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Small GTPase Mediated Signal Transduction Gene Expression Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process
Pathways			IRE1alpha activates chaperones Translation SRP-dependent cotranslational protein targeting to membrane XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Epilepsy (generalized) ( 22949513)	Alcohol consumption (transferrin glycosylation) ( 21665994)
Protein-Protein Interactions		11 interactors: CDK5R1 CREBBP CRMP1 DGCR14 DISC1 FKBP6 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4	2 interactors: CDK5RAP3 RCHY1
Entrez ID		80279	58477
HPRD ID		12190	18105
Ensembl ID		ENSG00000108465	ENSG00000144867
Uniprot IDs		B7Z6N4 F5H3I5 Q96JB5	Q549N5 Q9Y5M8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cerebral Cortex Radially Oriented Cell Migration Positive Regulation Of Protein Modification Process Cerebral Cortex Cell Migration Superior Olivary Nucleus Maturation Telencephalon Cell Migration Forebrain Cell Migration Positive Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Pons Maturation N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Metabolic Process Serine Phosphorylation Of STAT3 Protein Cerebral Cortex Development Germ-line Stem Cell Maintenance Serine Phosphorylation Of STAT Protein Neuron Migration Signal Transduction Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Catalytic Activity Negative Regulation Of Protein Localization To Cell Surface Activation Of MAPKKK Activity Pallium Development Regulation Of Protein Kinase Activity	Protein Ufmylation Protein Modification By Small Protein Conjugation
Tagcloud ?		anchors aspartate ataxin atx1 autonomous bergmann cerebellum collectively consistently downregulated eventually glia glutamate helix interacting knockin maxer mediates mediating mutant named purkinje represses repression rescues sca1 strengthened transporter vulnerability	15k cdnas characters clustering developmentally dncic2 dosage ds eef1g eif3sf extra hchr21 hierarchical manifested mrpl10 mrps18a neurogenesis neuron neuropathological outgrowth patterned peg3 phenotypic retardation sf3a60 snapc3 syngr2 tt2f ubce8
Tagcloud (Difference) ?		anchors aspartate ataxin atx1 autonomous bergmann cerebellum collectively consistently downregulated eventually glia glutamate helix interacting knockin maxer mediates mediating mutant named purkinje represses repression rescues sca1 strengthened transporter vulnerability	15k cdnas characters clustering developmentally dncic2 dosage ds eef1g eif3sf extra hchr21 hierarchical manifested mrpl10 mrps18a neurogenesis neuron neuropathological outgrowth patterned peg3 phenotypic retardation sf3a60 snapc3 syngr2 tt2f ubce8
Tagcloud (Intersection) ?