CDK5RAP3 and TAB1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CDK5RAP3	TAB1
Description		CDK5 regulatory subunit associated protein 3	TGF-beta activated kinase 1 (MAP3K7) binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Protein-containing Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endosome Membrane Membrane Protein-containing Complex
	Molecular Function	Protein Binding Protein Kinase Binding Cyclin Binding Ubiquitin-like Protein Ligase Binding Mitogen-activated Protein Kinase Binding NF-kappaB Binding MDM2/MDM4 Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Protein Serine/threonine Phosphatase Activity Protein Binding Kinase Activator Activity Protein Serine/threonine Kinase Activator Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase P38 Binding Molecular Adaptor Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Liver Development Negative Regulation Of Protein Phosphorylation Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Brain Development Blood Circulation Cell Population Proliferation Regulation Of Phosphatase Activity Apoptotic Nuclear Changes Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Ribosome Disassembly Response To Endoplasmic Reticulum Stress Negative Regulation Of Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Mitotic G2/M Transition Checkpoint Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Definitive Erythrocyte Differentiation Protein Ufmylation Negative Regulation Of Protein Serine/threonine Kinase Activity Rescue Of Stalled Ribosome Positive Regulation Of Reticulophagy Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process	In Utero Embryonic Development Heart Morphogenesis Cardiac Septum Development Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Lung Development Positive Regulation Of Type I Interferon Production Protein Exit From Endoplasmic Reticulum Aorta Development Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Coronary Vasculature Development CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
Pathways			NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1-dependent IKK and NF-kappa-B activation activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NF-kappa-B signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway SARS-CoV-2 activates/modulates innate and adaptive immune responses IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs			Manganese
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971) Generalized epilepsy ( 22949513) Metabolite levels (Pyroglutamine) ( 23934736)	Factor VIII levels ( 30586737) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Schizophrenia ( 29483656) Serum alkaline phosphatase levels ( 33547301) Sleep duration (short sleep) ( 30846698) vWF levels ( 30586737) Waist circumference ( 28552196)
Interacting Genes		13 interacting genes: CDK5R1 CREBBP CRMP1 DISC1 ESS2 FKBP6 HSPB1 KPNA2 SRPRB TAB1 TAX1BP3 TSPYL4 VHL	76 interacting genes: AATK ACAP3 APOA2 ARAP1 ASRGL1 BMPR1A C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A DBN1 DVL2 EGFR EPRS1 ERBB4 FADD FN1 GIT1 HNRNPR IKBKG ITCH KIFC2 LAP3 LCMT1 LGALS7 LGALS7B LNX2 MAP3K1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 ROR2 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SMURF1 SNRNP35 TAB2 TAB3 TRAF2 TRAF6 TRIM26 TRIP6 TRPC4AP TSSC4 UBC URB1 WDCP WTAP XIAP XPO7 YWHAG ZMYND11
Entrez ID		80279	10454
HPRD ID		12190	04012
Ensembl ID		ENSG00000108465	ENSG00000100324
Uniprot IDs		Q96JB5	A8K6K3 Q15750
PDB IDs		8OHD 8OJ0 8OJ5 8QFC	2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L52 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5NZZ 5O90 5V5N 5VVU 7NTH 7NTI 8GW3 8XI8 9FPD
Enriched GO Terms of Interacting Partners?		Contractile Muscle Fiber Cell Surface Receptor Signaling Pathway Regulation Of Postsynapse Organization Non-canonical NF-kappaB Signal Transduction Cerebral Cortex Cell Migration Cerebral Cortex Radially Oriented Cell Migration Molecular Adaptor Activity Telencephalon Cell Migration Forebrain Cell Migration	Regulation Of Intracellular Signal Transduction P38MAPK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Canonical NF-kappaB Signal Transduction Negative Regulation Of Intracellular Signal Transduction Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Signal Transduction Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cytosol Intracellular Signaling Cassette Negative Regulation Of Signal Transduction MAPK Cascade Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Programmed Cell Death Cytoplasm Regulation Of Cytokine Production Regulation Of Protein Metabolic Process Positive Regulation Of Signaling Negative Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Multicellular Organismal Process Regulation Of Apoptotic Process Activin Receptor Binding Positive Regulation Of Growth Positive Regulation Of Signal Transduction Positive Regulation Of Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Proteolysis Regulation Of JNK Cascade Cellular Response To Growth Factor Stimulus Protein Polyubiquitination Endosome Membrane Regulation Of Protein Modification Process Cell Surface Receptor Signaling Pathway Regulation Of T Cell Mediated Immunity Protein-containing Complex Protein Metabolic Process Regulation Of Necroptotic Process TORC1 Signaling Apoptotic Process Response To Virus Positive Regulation Of Macromolecule Metabolic Process
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