ALPK1 and TIFA

Number of citations of the paper that reports this interaction (PubMedID 36098982)
60

Data Source:
BioGRID (enzymatic study)

		ALPK1	TIFA
Description		alpha kinase 1	TRAF interacting protein with forkhead associated domain
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection	Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Monosaccharide Binding Protein Serine Kinase Activity	Protein Binding
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Cilium Assembly	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Homooligomerization
Pathways		TAK1-dependent IKK and NF-kappa-B activation Alpha-protein kinase 1 signaling pathway	TAK1-dependent IKK and NF-kappa-B activation Alpha-protein kinase 1 signaling pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Epirubicin-induced leukopenia ( 21799462) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Obesity ( 22484627) Subcortical volume (MOSTest) ( 32665545)	Body mass index ( 26426971) Rheumatoid arthritis ( 30891314)
Interacting Genes		1 interacting genes: TIFA	25 interacting genes: ALPK1 AP1M1 ARHGEF39 DVL2 GSDME IRAK1 KANK2 LNX1 LNX2 NIF3L1 NTAQ1 NUDT18 NXF1 PRKAA2 RIPPLY3 RPL9 SDCBP SDCBP2 TIFAB TNFAIP3 TNFAIP8 TRAF1 TRAF2 TRAF6 TXN2
Entrez ID		80216	92610
HPRD ID		09554	09835
Ensembl ID		ENSG00000073331	ENSG00000145365
Uniprot IDs		Q96QP1	Q96CG3
PDB IDs		5Z2C	4YM4 4ZGI 5ZUJ 6A33
Enriched GO Terms of Interacting Partners?			Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Intracellular Signal Transduction Innate Immune Response-activating Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Identical Protein Binding Cytoplasmic Pattern Recognition Receptor Signaling Pathway Activation Of Innate Immune Response Tumor Necrosis Factor Receptor Binding Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Ubiquitin-protein Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of JNK Cascade Interleukin-33-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway Thioesterase Binding CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Interleukin-2 Production CD40 Receptor Complex Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Regulation Of Programmed Cell Death Immune Response-activating Signaling Pathway Phosphatidylinositol-4,5-bisphosphate Binding Signaling Adaptor Activity Regulation Of Apoptotic Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cell Death Programmed Cell Death Immune Response-regulating Signaling Pathway Intracellular Receptor Signaling Pathway Activation Of Immune Response Regulation Of Immune Response Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Defense Response Positive Regulation Of Immune System Process Regulation Of Signal Transduction Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
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