JADE1 and AP2M1

		JADE1	AP2M1
Description		jade family PHD finger 1	adaptor related protein complex 2 subunit mu 1
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GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Ciliary Basal Body Cell Projection	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Extracellular Exosome Postsynapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding
	Biological Process	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Protein Transport Vesicle-mediated Transport Receptor Internalization Synaptic Vesicle Endocytosis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		HATs acetylate histones	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810) Bone mineral density (total hip) ( 29883787)	Major depressive disorder ( 22472876)
Interacting Genes		16 interacting genes: AKT1 CFTR CTNNB1 H3C14 H4C1 HMOX2 PFDN1 SEPTIN8 SMN1 TK1 UBE2E1 UBE2H UBE3A VHL YJU2 ZNF148	86 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATG9A ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD2BP2 CD3D CDK11B CEBPA CLK2 CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HOOK2 HTR6 IKZF1 IRS2 KCNJ11 KNOP1 LAMP1 LTB4R2 LUC7L2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 SNCA SPATS2 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TIAM1 TMA16 UBC ZBTB8A ZNF581
Entrez ID		79960	1173
HPRD ID		10151	03014
Ensembl ID		ENSG00000077684	ENSG00000161203
Uniprot IDs		B4E2E2 Q6IE81	B4DNB9 E9PFW3 Q96CW1
PDB IDs		8GDX 8GE0	1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of TOR Signaling Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Regulation Of TORC1 Signaling Protein K48-linked Ubiquitination Regulation Of Protein Localization Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Catabolic Process Disordered Domain Specific Binding Macromolecule Catabolic Process Regulation Of TOR Signaling 14-3-3 Protein Binding Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Enzyme Binding Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Protein Localization To Cell Surface Negative Regulation Of Intracellular Signal Transduction Protein K11-linked Ubiquitination Protein-containing Complex Regulation Of Myelination Proteolysis Regulation Of TRNA Methylation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein-containing Complex Assembly Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Sperm Entry Positive Regulation Of Golgi Lumen Acidification Nucleus Response To Ketone Regulation Of Cellular Localization Microtubule Cytoskeleton Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of TORC1 Signaling Negative Regulation Of Protein Localization To Lysosome Regulation Of Post-translational Protein Modification	Innate Immune Response In Mucosa Mucosal Immune Response Organ Or Tissue Specific Immune Response Protein-containing Complex Organization Protein-containing Complex Assembly Protein Heterodimerization Activity Structural Constituent Of Chromatin Antibacterial Humoral Response Nucleosome Assembly Protein Domain Specific Binding Nucleosome Nucleosome Organization Protein-DNA Complex Assembly AP-2 Adaptor Complex Import Into Cell Endocytosis Receptor-mediated Endocytosis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Gram-positive Bacterium Synaptic Vesicle Endocytosis Synaptic Vesicle Uncoating Presynaptic Endocytosis Trans-synaptic Signaling Clathrin Adaptor Activity Synaptic Signaling Clathrin Coat Assembly Nucleoplasm Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Antimicrobial Humoral Response Positive Regulation Of Endocytosis Clathrin Coat Disassembly Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Vesicle Uncoating Nucleus Positive Regulation Of Receptor Internalization Synaptic Membrane Protein Binding Cellular Component Assembly NMDA Glutamate Receptor Activity Synapse Clathrin-dependent Endocytosis Synaptic Vesicle Regulation Of Vesicle-mediated Transport NMDA Selective Glutamate Receptor Complex
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