JADE1 and YJU2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		JADE1	YJU2
Description		jade family PHD finger 1	YJU2 splicing factor homolog
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GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Ciliary Basal Body Cell Projection	Nucleus Nucleoplasm Spliceosomal Complex U2-type Catalytic Step 1 Spliceosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Histone H3K14 Acetyltransferase Activity Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Metal Ion Binding Histone H4K16 Acetyltransferase Activity	Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Regulation Of DNA Replication Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Growth Positive Regulation Of DNA-templated Transcription Regulation Of Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of DNA Biosynthetic Process	Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Pathways		HATs acetylate histones	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Arterial stiffness index ( 31235810) Bone mineral density (total hip) ( 29883787)
Interacting Genes		16 interacting genes: AKT1 CFTR CTNNB1 H3C14 H4C1 HMOX2 PFDN1 SEPTIN8 SMN1 TK1 UBE2E1 UBE2H UBE3A VHL YJU2 ZNF148	22 interacting genes: BANP BRAP CCDC57 CEP70 DRC4 EMILIN1 FRS2 GOLGA2 GOLGA6A JADE1 KAT5 LNX2 MAD1L1 MEOX2 REL TFCP2 TRIM15 TRIM21 TRIM27 ZNF143 ZNF526 ZNF829
Entrez ID		79960	55702
HPRD ID		10151	08546
Ensembl ID		ENSG00000077684	ENSG00000105248
Uniprot IDs		B4E2E2 Q6IE81	Q9BW85
PDB IDs		8GDX 8GE0	5YZG 6ZYM 7A5P 8I0W
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Negative Regulation Of TOR Signaling Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activity Post-translational Protein Modification Regulation Of TORC1 Signaling Protein K48-linked Ubiquitination Regulation Of Protein Localization Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Catabolic Process Disordered Domain Specific Binding Macromolecule Catabolic Process Regulation Of TOR Signaling 14-3-3 Protein Binding Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Enzyme Binding Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Regulation Of Protein Localization To Cell Surface Negative Regulation Of Intracellular Signal Transduction Protein K11-linked Ubiquitination Protein-containing Complex Regulation Of Myelination Proteolysis Regulation Of TRNA Methylation Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Protein-containing Complex Assembly Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Sperm Entry Positive Regulation Of Golgi Lumen Acidification Nucleus Response To Ketone Regulation Of Cellular Localization Microtubule Cytoskeleton Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of TORC1 Signaling Negative Regulation Of Protein Localization To Lysosome Regulation Of Post-translational Protein Modification	Suppression Of Viral Release By Host Regulation Of Type I Interferon Production Canonical NF-kappaB Signal Transduction Zinc Ion Binding Transcription Coactivator Activity Positive Regulation Of Mitotic Sister Chromatid Segregation Histone H4K16 Acetyltransferase Activity Golgi Cis Cisterna Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Organelle Disassembly Regulation Of Metaphase Plate Congression Positive Regulation Of Biosynthetic Process Identical Protein Binding Negative Regulation Of Viral Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Viral Transcription Ubiquitin-protein Transferase Activity Attachment Of Mitotic Spindle Microtubules To Kinetochore Membraneless Organelle Assembly Histone Acetyltransferase Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Microtubule Nucleation DNA Binding Regulation Of Viral Process Positive Regulation Of Chromosome Segregation Positive Regulation Of Cell Cycle Spindle Pole Ubiquitin Protein Ligase Activity Mitotic Spindle Pole Attachment Of Spindle Microtubules To Kinetochore Regulation Of Autophagy Innate Immune Response MAD1 Complex Histone H2AK5 Acetyltransferase Activity Regulation Of Protein Binding Positive Regulation Of Autophagy Negative Regulation Of Type I Interferon Production Positive Regulation Of Metabolic Process Cytoskeleton Cis-Golgi Network Organelle Assembly DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Microtubule Cytoskeleton Organization Defense Response To Other Organism Defense Response To Symbiont
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