RALGPS1 and AKAP19

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RALGPS1	AKAP19
Description		Ral GEF with PH domain and SH3 binding motif 1	A-kinase anchoring protein 19
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction Regulation Of Ral Protein Signal Transduction Intracellular Signal Transduction
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Early-onset schizophrenia ( 33907183) Intraocular pressure ( 29617998 29785010 31959993) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Post bronchodilator FEV1/FVC ratio ( 26634245) Schizophrenia ( 30285260)
Interacting Genes		5 interacting genes: AKAP19 APP CEP76 GRB2 RALA	11 interacting genes: ARMC7 BATF2 CENPP FBXO7 MYOD1 NFKBIL1 PRKAR1A PRKAR2B RALGPS1 TDP2 ZMIZ2
Entrez ID		9649	84281
HPRD ID		11479	14436
Ensembl ID		ENSG00000136828	ENSG00000187699
Uniprot IDs		Q5JS13	Q9BSF0
PDB IDs		3QXL	5HVZ
Enriched GO Terms of Interacting Partners?		Amyloid-beta Complex Growth Cone Lamellipodium Synaptic Membrane Regulation Of Response To Calcium Ion Amylin Binding Ephrin Receptor Binding Positive Regulation Of Toll Signaling Pathway Endocytosis Regulation Of Receptor Internalization Positive Regulation Of Reactive Oxygen Species Metabolic Process Glial Cell Development Receptor Internalization Guanyl-nucleotide Exchange Factor Adaptor Activity Ras Protein Signal Transduction Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Regulation Of Reactive Oxygen Species Metabolic Process Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Lipoprotein Particle Import Into Cell Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Grb2-EGFR Complex Edg-2 Lysophosphatidic Acid Receptor Binding Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intracellular Signaling Cassette Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Receptor-mediated Endocytosis Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Neurotrophin TRKA Receptor Binding Regulation Of Cellular Component Organization	CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Regulation Of CAMP/PKA Signal Transduction Ciliary Base Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite 5'-tyrosyl-DNA Phosphodiesterase Activity Tyrosyl-RNA Phosphodiesterase Activity Tyrosyl-DNA Phosphodiesterase Activity Myoblast Fate Determination Negative Regulation Of Intracellular Signal Transduction Response To Antipsychotic Drug Regulation Of Ral Protein Signal Transduction
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