DHDDS and LOX

Number of citations of the paper that reports this interaction (PubMedID 15110773)
0

Data Source:
HPRD (two hybrid)

		DHDDS	LOX
Description		dehydrodolichyl diphosphate synthase subunit	lysyl oxidase
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dehydrodolichyl Diphosphate Synthase Complex	Extracellular Region Collagen Trimer Extracellular Space Extracellular Matrix
	Molecular Function	Prenyltransferase Activity Protein Binding Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Metal Ion Binding	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding Collagen Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Small Molecule Binding Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Protein Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Polyprenol Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process	Blood Vessel Development Osteoblast Differentiation Heart Development Response To Xenobiotic Stimulus Response To Hormone Regulation Of Gene Expression Regulation Of Striated Muscle Tissue Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-lysine Oxidation Collagen Fibril Organization Bone Mineralization Lung Development Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Development Ascending Aorta Development Descending Aorta Development Protein Modification Process Regulation Of Apoptotic Process Regulation Of Megakaryocyte Differentiation Muscle Cell Cellular Homeostasis Elastic Fiber Assembly Blood Vessel Morphogenesis Response To Steroid Hormone Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Muscle Cell Development Cell Chemotaxis Connective Tissue Development DNA Biosynthetic Process Regulation Of Bone Development Cellular Response To Chemokine Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Synthesis of dolichyl-phosphate Defective DHDDS causes RP59	Elastic fibre formation Crosslinking of collagen fibrils
Drugs
Diseases
GWAS		Caffeine consumption from tea ( 33287642) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Serum alkaline phosphatase levels ( 33339817)	Central corneal thickness ( 32528159) Coronary artery disease ( 28714974) Intraocular pressure ( 29617998) Keratoconus ( 33649486) Lung function (FEV1/FVC) ( 30804560) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Waist circumference adjusted for body mass index ( 34021172) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		3 interacting genes: LOX MT-ND1 NPC2	8 interacting genes: DHDDS DPT ELN H1-1 H1-5 H2BC11 H2BC21 MRE11
Entrez ID		79947	4015
HPRD ID		12183	01087
Ensembl ID		ENSG00000117682	ENSG00000113083
Uniprot IDs		Q86SQ9	B0AZT2 B7ZAJ4 D0PNI2 P28300
PDB IDs		6W2L 6Z1N 7PAX 7PAY 7PB0 7PB1
Enriched GO Terms of Interacting Partners?		Descending Aorta Development Ascending Aorta Development Organelle Envelope Peptidyl-lysine Oxidation Response To Xenobiotic Stimulus Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Mitochondrial Membrane Cholesterol Storage Glycolipid Transport Sterol Binding Regulation Of Isoprenoid Metabolic Process Regulation Of Bone Development Elastic Fiber Assembly NADH Dehydrogenase Activity Response To Oxidative Stress Regulation Of Interleukin-1-mediated Signaling Pathway Cellular Response To Chemokine	Structural Constituent Of Chromatin Nucleosome Nucleosome Assembly Nucleosome Organization Chromatin Remodeling Chromosome Protein-DNA Complex Assembly Chromatin Organization Innate Immune Response In Mucosa Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Phosphatidylinositol Phosphate Binding Mucosal Immune Response Organ Or Tissue Specific Immune Response Chromosome Condensation Nucleosomal DNA Binding Regulation Of DNA Metabolic Process Negative Regulation Of DNA Recombination Mitochondrial Double-strand Break Repair Via Homologous Recombination Nicotinamide Phosphoribosyltransferase Activity Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Euchromatin Antibacterial Humoral Response Myosin II Heavy Chain Binding Histone H2AXY142 Phosphatase Activity Chromatin DNA Binding
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?