DHDDS

Gene Name		dehydrodolichyl diphosphate synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Synthesis of Dolichyl-phosphate Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: LOX ND1 NPC2
Entrez ID		79947
HPRD ID		12183
Ensembl ID		ENSG00000117682
Uniprot IDs		Q86SQ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Isoprenoid Metabolic Process Elastic Fiber Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Glycolipid Transport Extracellular Matrix Assembly
Tagcloud ?		agglutinin appearance cone degeneration dehydrodolichol diphosphate enzymatic injected insufficient knocked missing mo modeling morpholino oligonucleotides outer peanut photoreceptor pigmentosa pna recessive respond retinal retinas retinitis rp segments visual zebrafish