DHDDS and MT-ND1

Number of citations: 0 (PubMedID 15110773)
Data Source: HPRD (two hybrid)

		DHDDS	MT-ND1
Name		dehydrodolichyl diphosphate synthase subunit	NADH dehydrogenase subunit 1
Structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dehydrodolichyl Diphosphate Synthase Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Dendrite Mitochondrial Membrane Neuronal Cell Body Respiratory Chain Complex I
	Molecular Function	Prenyltransferase Activity Protein Binding Transferase Activity Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Metal Ion Binding	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Protein Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Polyprenol Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process	Response To Hypoxia Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Response To Xenobiotic Stimulus Mitochondrial Respiratory Chain Complex I Assembly Response To Hydroperoxide Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways		Synthesis of dolichyl-phosphate Defective DHDDS causes RP59	Mitochondrial translation termination Respiratory electron transport Complex I biogenesis Mitochondrial protein degradation
Drugs		None	NADH Methoxyflurane Halothane Desflurane Sevoflurane N-Formylmethionine Phenethyl Isothiocyanate
Diseases		None	Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS		Caffeine consumption from tea ( 33287642 ) FEV1 ( 30804560 ) Lung function (FVC) ( 30804560 ) Peak expiratory flow ( 30804560 ) Serum alkaline phosphatase levels ( 33339817 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: VRK2	None recorded
Interacting Genes		3 interacting genes: LOX MT-ND1 NPC2	13 interacting genes: BARD1 BRCA1 DHDDS FAT1 LIG4 MEOX2 NDUFS7 PAXIP1 RPL13A RPL6 SIRPA TSC1 TST
Entrez ID		79947	4535
HPRD ID		12183	08365
Ensembl ID		ENSG00000117682	ENSG00000198888
Uniprot IDs		Q86SQ9	P03886 U5Z754
PDB IDs		6W2L 6Z1N 7PAX 7PAY 7PB0 7PB1	5XTC 5XTD
GO Terms Enriched among Interactors		Descending Aorta Development Ascending Aorta Development Organelle Envelope Peptidyl-lysine Oxidation Response To Xenobiotic Stimulus Platelet-derived Growth Factor Receptor-beta Signaling Pathway Protein-lysine 6-oxidase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Protein Oxidation Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Mitochondrial Membrane Cholesterol Storage Glycolipid Transport Sterol Binding Regulation Of Isoprenoid Metabolic Process Regulation Of Bone Development Elastic Fiber Assembly NADH Dehydrogenase Activity Response To Oxidative Stress Regulation Of Interleukin-1-mediated Signaling Pathway Cellular Response To Chemokine	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex BRCA1-B Complex Response To Ionizing Radiation Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Cellular Response To Ionizing Radiation DNA Recombination DNA Strand Resection Involved In Replication Fork Processing Regulation Of Cell Cycle G2/M Phase Transition Large Ribosomal Subunit Regulation Of DNA Damage Checkpoint Protein K6-linked Ubiquitination Cellular Response To Radiation Response To Radiation Condensed Chromosome Homologous Recombination DNA Repair Mitotic G2/M Transition Checkpoint Cellular Response To Stress Negative Regulation Of MRNA 3'-end Processing Establishment Of Epithelial Cell Apical/basal Polarity Involved In Camera-type Eye Morphogenesis Establishment Of Integrated Proviral Latency Memory T Cell Differentiation Negative Regulation Of Formation Of Translation Preinitiation Complex Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Cytosolic Large Ribosomal Subunit Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Establishment Of Viral Latency Cyanate Catabolic Process 3-mercaptopyruvate Sulfurtransferase Activity Negative Regulation Of Cytoplasmic Translational Initiation Cellular Response To Type II Interferon Cellular Response To Interleukin-12 DNA Metabolic Process Cytoplasmic Ribonucleoprotein Granule Ubiquitin Ligase Complex DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Ribonucleoprotein Complex DNA Ligase (ATP) Activity DNA Ligase IV Complex Pro-B Cell Differentiation T Cell Receptor V(D)J Recombination