DHDDS and ND1

Number of citations of the paper that reports this interaction (PMID 15110773)
4

Data Source:
HPRD (two hybrid)

		DHDDS	ND1
Gene Name		dehydrodolichyl diphosphate synthase	NADH dehydrogenase, subunit 1 (complex I)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Transferase Activity, Transferring Alkyl Or Aryl (other Than Methyl) Groups
	Biological Process	Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Synthesis of Dolichyl-phosphate Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: LOX ND1 NPC2	10 interactors: BARD1 BRCA1 DHDDS LIG4 MEOX2 NDUFS7 PAXIP1 RPL13A RPL6 TST
Entrez ID		79947	4535
HPRD ID		12183	08365
Ensembl ID		ENSG00000117682
Uniprot IDs		Q86SQ9	P03886 Q85KV6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Isoprenoid Metabolic Process Elastic Fiber Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Glycolipid Transport Extracellular Matrix Assembly	Protein K6-linked Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Nitrogen Compound Metabolic Process Positive Regulation Of Histone Acetylation Response To Ionizing Radiation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Peptidyl-lysine Acetylation Positive Regulation Of Protein Acetylation Nucleobase-containing Compound Metabolic Process DNA Repair Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Histone Methylation DNA Recombination Cellular Macromolecule Biosynthetic Process Regulation Of Histone Acetylation Macromolecule Biosynthetic Process Regulation Of Histone Methylation Cellular Metabolic Process Cellular Response To DNA Damage Stimulus Neuron Death Positive Regulation Of Histone Modification Positive Regulation Of Histone H4-K20 Methylation Negative Regulation Of Formation Of Translation Preinitiation Complex Positive Regulation Of Histone H3-K36 Methylation DNA Ligation Involved In DNA Recombination Positive Regulation Of Histone H4-K16 Acetylation DNA Damage Response, Signal Transduction By P53 Class Mediator Viral Transcription DNA Metabolic Process Signal Transduction In Response To DNA Damage Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Response To Radiation Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of Histone H3-K9 Acetylation Negative Regulation Of MRNA 3'-end Processing Cyanate Catabolic Process Biosynthetic Process Signal Transduction By P53 Class Mediator Regulation Of Histone Modification Protein Localization To Endoplasmic Reticulum Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation RNA Import Into Mitochondrion RRNA Import Into Mitochondrion Viral Process
Tagcloud ?		agglutinin appearance cone degeneration dehydrodolichol diphosphate enzymatic injected insufficient knocked missing mo modeling morpholino oligonucleotides outer peanut photoreceptor pigmentosa pna recessive respond retinal retinas retinitis rp segments visual zebrafish	12s 16s 18s coi cys distinction eastern genus honshu japan markers mature met mitochondrial mountainous oka orobdella orobdellamasaakikuroiwai orobdellawhitmani phylogenetic phylogroups quadrannulate rdna relationships reveled sister sp trna val
Tagcloud (Difference) ?		agglutinin appearance cone degeneration dehydrodolichol diphosphate enzymatic injected insufficient knocked missing mo modeling morpholino oligonucleotides outer peanut photoreceptor pigmentosa pna recessive respond retinal retinas retinitis rp segments visual zebrafish	12s 16s 18s coi cys distinction eastern genus honshu japan markers mature met mitochondrial mountainous oka orobdella orobdellamasaakikuroiwai orobdellawhitmani phylogenetic phylogroups quadrannulate rdna relationships reveled sister sp trna val
Tagcloud (Intersection) ?