UBXN8 and SFRP1

Data Source: HiPPIP (Novel)

		UBXN8	SFRP1
Name		UBX domain protein 8	secreted frizzled related protein 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Binding	Cysteine-type Endopeptidase Activity Frizzled Binding Protein Binding Heparin Binding Wnt-protein Binding Identical Protein Binding
	Biological Process	Single Fertilization ERAD Pathway	Osteoblast Differentiation Ureteric Bud Development Somitogenesis Neural Tube Closure Positive Regulation Of Cell-matrix Adhesion Hematopoietic Progenitor Cell Differentiation Regionalization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Male Gonad Development Female Gonad Development Cellular Response To Starvation Response To Xenobiotic Stimulus Dorsal/ventral Axis Specification Anterior/posterior Pattern Specification Regulation Of Cell Cycle Process Negative Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Neuron Projection Development Neural Crest Cell Fate Commitment Wnt Signaling Pathway Neural Tube Development Hemopoiesis Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Osteoclast Differentiation Negative Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Proliferation Somatic Stem Cell Population Maintenance Non-canonical Wnt Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of B Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Angiogenesis Positive Regulation Of Smoothened Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Development Of Primary Male Sexual Characteristics Negative Regulation Of Bone Remodeling Negative Regulation Of Fibroblast Proliferation Digestive Tract Morphogenesis Stem Cell Differentiation Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Hematopoietic Stem Cell Differentiation Bone Trabecula Formation Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Vitamin D Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Prostaglandin E Stimulus Cellular Response To Estrogen Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Hypoxia Cellular Response To X-ray Dopaminergic Neuron Differentiation Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Wnt Signaling Pathway Involved In Somitogenesis Convergent Extension Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Midbrain Dopaminergic Neuron Differentiation Positive Regulation Of Non-canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Fibroblast Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		None	TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists
GWAS		No GWAS studies recorded	Academic attainment (English) ( 33594131 ) Anti-saccade response ( 29064472 ) Appendicular lean mass ( 33097823 ) Blood protein levels ( 30072576 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Refractive astigmatism ( 30306274 )
Novel Interactors		6 novel interactors: ADRB3 DCTN6 LINC03042 RBPMS SFRP1 WRN	2 novel interactors: IDO1 UBXN8
Interacting Genes		7 interacting genes: AQP6 GJA8 HSD17B13 MEOX2 PGRMC2 SPCS1 TMEM14B	8 interacting genes: FZD6 NHSL3 PPP1CA PPP1CC TMEM86B WNT1 WNT2 WNT4
Entrez ID		7993	6422
HPRD ID		03692	09165
Ensembl ID		ENSG00000104691	ENSG00000104332
Uniprot IDs		A0A087WUA4 A0A087WV67 B4DKK1 O00124	Q8N474
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		None	Cell Proliferation In Midbrain Canonical Wnt Signaling Pathway Positive Regulation Of Dermatome Development Frizzled Binding PTW/PP1 Phosphatase Complex Wnt Signaling Pathway Regulation Of Embryonic Development Mammary Gland Epithelium Development Neural Precursor Cell Proliferation Midbrain Dopaminergic Neuron Differentiation Cell Population Proliferation Neuron Differentiation Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Embryonic Development Receptor Ligand Activity Tissue Morphogenesis Central Nervous System Neuron Differentiation Entrainment Of Circadian Clock By Photoperiod Morphogenesis Of A Branching Epithelium Protein Phosphatase 1 Binding Morphogenesis Of A Branching Structure Photoperiodism Entrainment Of Circadian Clock Cell Fate Commitment Developmental Induction Midbrain Development Dopaminergic Neuron Differentiation Cytokine Activity Branching Involved In Ureteric Bud Morphogenesis T Cell Differentiation In Thymus Cell Activation Non-canonical Wnt Signaling Pathway T Cell Activation Tube Morphogenesis Glycogen Metabolic Process Midbrain-hindbrain Boundary Maturation During Brain Development Cerebellum Formation Positive Regulation Of Fibroblast Proliferation Inner Ear Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis D-lysine 5,6-aminomutase Activity Circadian Regulation Of Gene Expression Regulation Of Morphogenesis Of An Epithelium Morphogenesis Of An Epithelium Anatomical Structure Morphogenesis