UBXN8 and SPCS1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		UBXN8	SPCS1
Name		UBX domain protein 8	signal peptidase complex subunit 1
Structure		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Nucleolus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Signal Peptidase Complex Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Ubiquitin Binding	Protein Binding
	Biological Process	Single Fertilization ERAD Pathway	Signal Peptide Processing Proteolysis Virion Assembly Viral Protein Processing Protein Targeting To ER
Pathways		None	SRP-dependent cotranslational protein targeting to membrane Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin Regulation of CDH1 posttranslational processing and trafficking to plasma membrane Maturation of hRSV A proteins
GWAS		No GWAS studies recorded	Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 21926972 31043756 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Feeling worry ( 29500382 ) Schizophrenia ( 23974872 25056061 28991256 29483656 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Novel Interactors		6 novel interactors: ADRB3 DCTN6 LINC03042 RBPMS SFRP1 WRN	None recorded
Interacting Genes		7 interacting genes: AQP6 GJA8 HSD17B13 MEOX2 PGRMC2 SPCS1 TMEM14B	9 interacting genes: AQP2 FIS1 FXYD6-FXYD2 RPRM SLC22A2 SLC25A46 TMEM74 UBXN8 YIPF2
Entrez ID		7993	28972
HPRD ID		03692	07155
Ensembl ID		ENSG00000104691	ENSG00000114902
Uniprot IDs		A0A087WUA4 A0A087WV67 B4DKK1 O00124	A0A5F9YFS9 Q9Y6A9
PDB IDs		Not available	7P2P 7P2Q
GO Terms Enriched among Interactors		None	Mitochondrial Fission Lumenal Side Of Membrane Polyol Transmembrane Transport Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Cellular Response To Mercury Ion Metanephric Collecting Duct Development Cellular Response To Water Deprivation Organic Hydroxy Compound Transport Glycerol Transmembrane Transporter Activity Response To Mercury Ion Membrane Serotonin Uptake Acetylcholine Transport Histamine Uptake Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transport Norepinephrine Uptake Prostaglandin Transmembrane Transporter Activity Xenobiotic Transport Across Blood-brain Barrier Spermidine Transport Toxin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Epinephrine Transport Choline Transmembrane Transporter Activity Spermidine Transmembrane Transport Putrescine Transport Norepinephrine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Amine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity L-arginine Import Across Plasma Membrane Putrescine Transmembrane Transporter Activity Polyamine Transmembrane Transport Thiamine Transmembrane Transport Histamine Transport L-arginine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Response To Flavonoid Response To Fluoride Negative Regulation Of Fatty Acid Transport Response To Hypobaric Hypoxia Cellular Response To Peptide Golgi Trans Cisterna Golgi Medial Cisterna Mitochondrial Membrane Fission