GGNBP2 and GSDMB

Data Source: HiPPIP (Novel)

		GGNBP2	GSDMB
Name		gametogenetin binding protein 2	gasdermin B
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytoplasmic Vesicle	Cytoplasm Plasma Membrane Membrane
	Molecular Function	None	Phosphatidylserine Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Wide Pore Channel Activity Phosphatidylinositol-4-phosphate Binding Cardiolipin Binding
	Biological Process	Spermatogenesis Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Cell Differentiation Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Negative Regulation Of Receptor Signaling Pathway Via STAT	Programmed Cell Death Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Killing By Host Of Symbiont Cells Transmembrane Transport Pyroptotic Inflammatory Response Granzyme-mediated Programmed Cell Death Signaling Pathway Cytotoxic T Cell Pyroptotic Cell Death
GWAS		Adult body size ( 32376654 ) Body mass index ( 25673413 28892062 ) Body size at age 10 ( 32376654 ) Intelligence (MTAG) ( 29326435 )	Adult asthma ( 30787307 ) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359 ) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Allergic rhinitis ( 30013184 ) Allergy ( 27182965 ) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738 29273806 28461288 20860503 21804549 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 29273806 34022066 24241537 31036433 27611488 30929738 ) Asthma (time to onset) ( 27130862 ) Asthma onset (childhood vs adult) ( 30929738 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Atrial fibrillation ( 30061737 ) Bronchial hyperresponsiveness in asthma ( 27439200 ) Cervical cancer ( 23817570 ) Childhood asthma with severe exacerbations ( 33328473 ) Crohn's disease ( 28067908 ) Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Feeling miserable ( 29500382 ) Fractional exhaled nitric oxide (childhood) ( 24315451 ) IgM levels ( 28628107 ) Inflammatory bowel disease ( 23128233 28067908 ) Medication use (adrenergics, inhalants) ( 31015401 ) Medication use (glucocorticoids) ( 31015401 ) Monocyte percentage of white cells ( 27863252 ) Primary biliary cholangitis ( 23000144 20639880 30643196 ) Primary biliary cirrhosis ( 22961000 ) Refractive error ( 32231278 ) Rheumatoid arthritis ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676 ) Self-reported allergy ( 23817569 ) Serum alkaline phosphatase levels ( 33339817 ) Subcutaneous adipose tissue ( 27918534 ) Systemic lupus erythematosus ( 26502338 ) Systemic sclerosis ( 31672989 28314753 ) Type 1 diabetes ( 30659077 25751624 ) Ulcerative colitis ( 28067908 ) White blood cell count ( 21738480 32888494 )
Novel Interactors		1 novel interactors: GSDMB	9 novel interactors: CDK12 CWC25 DHRS11 FNDC8 GGNBP2 MRM1 MYO19 NLE1 SLFN12
Interacting Genes		1 interacting genes: GGN	8 interacting genes: AGT APP CLK1 HIVEP1 IGFBP2 ORM1 PEBP1 SERPINA1
Entrez ID		79893	55876
HPRD ID		18337	17082
Ensembl ID		ENSG00000278311	ENSG00000073605
Uniprot IDs		Q9H3C7	Q8TAX9
PDB IDs		8BFJ	5TIB 5TJ2 5TJ4 7WJQ 8EFP 8ET1 8ET2 8GTJ 8GTK 8GTN
GO Terms Enriched among Interactors		Cytotoxic T Cell Pyroptotic Cell Death Wide Pore Channel Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Pyroptotic Cell Death Phosphatidylinositol-4-phosphate Binding Killing By Host Of Symbiont Cells Biological Process Involved In Interaction With Symbiont Pyroptotic Inflammatory Response Phosphatidylserine Binding	Serine-type Endopeptidase Inhibitor Activity Platelet Alpha Granule Lumen Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Peptidase Inhibitor Activity