UBA5 and TMEM132D

Number of citations of the paper that reports this interaction (PubMedID 33726789)
50

Data Source:
BioGRID (two hybrid)

		UBA5	TMEM132D
Description		ubiquitin like modifier activating enzyme 5	transmembrane protein 132D
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Membrane
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Ubiquitin-like Modifier Activating Enzyme Activity Protein Homodimerization Activity Metal Ion Binding UFM1 Activating Enzyme Activity	Protein Binding
	Biological Process	Erythrocyte Differentiation Megakaryocyte Differentiation Regulation Of Type II Interferon Production Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Neuromuscular Process Reticulophagy Protein Ufmylation Protein K69-linked Ufmylation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anxiety disorder ( 25390645) Asthma ( 29273806) Blood protein levels ( 30072576) Body fat mass ( 28552196) Cognitive decline rate in late mild cognitive impairment ( 26252872) Heart rate ( 23534349) Initial pursuit acceleration ( 29064472) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Retinal venular tortuosity ( 31597446) Schizophrenia (inflammation and infection response interaction) ( 25781172) Sleep (1/2-day periodicity) ( 33075057) Triglyceride levels ( 34074324) Trunk fat mass ( 28552196) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		8 interacting genes: APEH GABARAPL2 OGT PKD1P1 TMEM132D UBE2D2 UBE2K UBE2L3	70 interacting genes: ANKRD31 ANKRD36 ARL3 ATP1B1 ATP7A BNIP3L CADPS2 CCDC85A CD59 CMPK1 CNGB3 CNTN1 COMMD1 COX11 CPD EFEMP1 ENOPH1 FAM106A FMO2 GFM2 H3C1 HDAC2 HEBP2 HNRNPUL1 HOXA9 IDI2-AS1 IL13RA1 LNX1 MIR181A1HG MME NAMPT NCKAP1 NDUFS5 NPAS3 PAIP1 PCCA PCLO PGM1 PLSCR2 PNISR PRMT3 PRPF40A PTPN2 PTPRD RAB6A RCBTB2 RNF2 SAMD12 SDHB SEC22B SHLD2 SLC35E2A SRSF5 STK39 SVIL TCF12 TMED5 TMED7-TICAM2 TNFAIP8 TOB2 TPST1 TRAPPC11 TRAPPC8 TUBGCP5 UBA5 UMOD USP32P2 VPS13C ZBTB20 ZNF302
Entrez ID		79876	121256
HPRD ID		15598	13906
Ensembl ID		ENSG00000081307	ENSG00000151952
Uniprot IDs		Q9GZZ9	Q14C87
PDB IDs		3GUC 3H8V 5HKH 5IA8 5IAA 5L95 6H77 6H78 6H8C 7NVK 7NW1 7OVC
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Proteolysis Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin Protein Ligase Binding Mitophagy Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Autophagy Of Mitochondrion Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Catabolic Process Protein K48-linked Ubiquitination Omega Peptidase Activity Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Protein-containing Complex Disassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Protein-containing Complex Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Macroautophagy Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Ubiquitination Protein Modification Process Ubiquitin-protein Transferase Activator Activity Regulation Of Transcription By Glucose Positive Regulation Of Peptidyl-threonine Phosphorylation Cellular Response To Nitrogen Starvation Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Transferase Activity NSL Complex Post-translational Protein Modification Regulation Of Post-translational Protein Modification	Golgi Vesicle Transport Protein Transport Into Plasma Membrane Raft Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process ATP Metabolic Process Nucleoside Phosphate Metabolic Process Protein Transport Into Membrane Raft Positive Regulation Of Potassium Ion Import Across Plasma Membrane Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Purine-containing Compound Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transport
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