UBA5 and APEH

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UBA5	APEH
Description		ubiquitin like modifier activating enzyme 5	acylaminoacyl-peptide hydrolase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Membrane	Extracellular Region Cytoplasm Cytosol Nuclear Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Zinc Ion Binding Ubiquitin-like Modifier Activating Enzyme Activity Protein Homodimerization Activity Metal Ion Binding UFM1 Activating Enzyme Activity	RNA Binding Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Omega Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	Erythrocyte Differentiation Megakaryocyte Differentiation Regulation Of Type II Interferon Production Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Neuromuscular Process Reticulophagy Protein Ufmylation Protein K69-linked Ufmylation	Translational Termination Proteolysis Amyloid-beta Metabolic Process
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Neutrophil degranulation Eukaryotic Translation Termination
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) Feeling tense ( 29500382) Feeling worry ( 29500382) Household income ( 31844048) Inflammatory bowel disease ( 28067908) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633 28067908)
Interacting Genes		8 interacting genes: APEH GABARAPL2 OGT PKD1P1 TMEM132D UBE2D2 UBE2K UBE2L3	7 interacting genes: CEBPA IST1 LGALS8 RUNX1 SHBG TMEM62 UBA5
Entrez ID		79876	327
HPRD ID		15598	00034
Ensembl ID		ENSG00000081307	ENSG00000164062
Uniprot IDs		Q9GZZ9	P13798
PDB IDs		3GUC 3H8V 5HKH 5IA8 5IAA 5L95 6H77 6H78 6H8C 7NVK 7NW1 7OVC
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Proteolysis Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin Protein Ligase Binding Mitophagy Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Proteasomal Protein Catabolic Process Autophagy Of Mitochondrion Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Catabolic Process Protein K48-linked Ubiquitination Omega Peptidase Activity Negative Regulation Of Protein Catabolic Process Protein O-acetylglucosaminyltransferase Activity Protein-containing Complex Disassembly Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Protein-containing Complex Organization Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Macroautophagy Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Ubiquitination Protein Modification Process Ubiquitin-protein Transferase Activator Activity Regulation Of Transcription By Glucose Positive Regulation Of Peptidyl-threonine Phosphorylation Cellular Response To Nitrogen Starvation Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Transferase Activity NSL Complex Post-translational Protein Modification Regulation Of Post-translational Protein Modification	Hematopoietic Stem Cell Proliferation Leukocyte Differentiation Stem Cell Proliferation Regulation Of Proteolysis Positive Regulation Of Cell Activation Myeloid Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding UFM1 Activating Enzyme Activity Core-binding Factor Complex Negative Regulation Of Hemopoiesis Regeneration CHOP-C/EBP Complex Response To Vitamin B2 C/EBP Complex Lymphatic Endothelial Cell Migration MIT Domain Binding Cardiac Muscle Tissue Regeneration Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Cell Activation White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Macroautophagy Androgen Binding Protein K69-linked Ufmylation Protein Homodimerization Activity DNA-binding Transcription Factor Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Plasma Cell Differentiation Positive Regulation Of Proteolysis Response To Phenylpropanoid Xenophagy Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Granulocyte Differentiation Fat Cell Proliferation Regulation Of Cell Development Protein Domain Specific Binding Positive Regulation Of Cell Differentiation Negative Regulation Of Granulocyte Differentiation ESCRT III Complex Disassembly ESCRT Complex Disassembly Ubiquitin-like Modifier Activating Enzyme Activity Protein Ufmylation Transcription Cis-regulatory Region Binding Positive Regulation Of T Cell Activation Peripheral Nervous System Neuron Development Urea Cycle
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