MIR19A and P3H1

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR19A	P3H1
Description		microRNA 19a	prolyl 3-hydroxylase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space RISC Complex Extracellular Exosome Extracellular Vesicle	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Membrane Extracellular Matrix Protein-containing Complex Extracellular Exosome
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Iron Ion Binding Protein Binding Collagen Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Procollagen-proline 3-dioxygenase Activity L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Fibroblast Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Toll-like Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By MRNA Destabilization B Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Inflammatory Response Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Cellular Response To Bacterial Lipopeptide Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Regulation Of Cardiac Conduction Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Matrix Metallopeptidase Secretion	Protein Folding Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Protein Hydroxylation Collagen Fibril Organization Regulation Of Ossification Negative Regulation Of Cell Growth Collagen Metabolic Process Regulation Of Protein Secretion Protein Stabilization Bone Development Negative Regulation Of Post-translational Protein Modification
Pathways			Collagen biosynthesis and modifying enzymes
Drugs			Ascorbic acid Proline
Diseases			Osteogenesis imperfecta
GWAS
Interacting Genes		99 interacting genes: AGO2 AIMP2 APOBEC3B ATXN2L C1QBP CELF1 CELF2 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CRTAP CSTF2 CSTF3 DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FIP1L1 FUS G3BP2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LIN28A LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT21 NUFIP2 P3H1 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBBP6 RBFOX2 RBM12B RBM14 RBM4 RBMS2 RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B U2SURP UPF1 UTP20 WDR33 WWP1 WWP2 YBX1 YBX2 YBX3 ZFR ZNF346 ZNF385A	13 interacting genes: CDC42 MIR1-2 MIR107 MIR141 MIR18B MIR19A MIR19B1 MIR9-3 MIR92A1 MIRLET7A2 MIRLET7B MIRLET7I SLC2A4
Entrez ID		406979	64175
HPRD ID			11227
Ensembl ID		ENSG00000284204	ENSG00000117385
Uniprot IDs			Q32P28
PDB IDs			8K0E 8K0F 8K0I 8K0M 8K17 8KC9
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Splicing MRNA Binding Nucleus Macromolecule Metabolic Process Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Ribonucleoprotein Complex MRNA Cleavage And Polyadenylation Specificity Factor Complex Nucleoplasm Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulation Of Translation RNA Splicing, Via Transesterification Reactions MRNA 3'-UTR Binding Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Aminoacyl-tRNA Synthetase Multienzyme Complex Cytoplasmic Stress Granule Spliceosomal Complex MiRNA Binding Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Negative Regulation Of Translation Negative Regulation Of RNA Catabolic Process RNA Stabilization RNA 3'-end Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 3'-end Processing Co-transcriptional RNA 3'-end Processing, Cleavage And Polyadenylation Pathway Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of MRNA Stability MRNA Stabilization Regulation Of RNA Stability Pre-mRNA Binding Positive Regulation Of Cytoplasmic Translation Co-transcriptional MRNA 3'-end Processing, Cleavage And Polyadenylation Pathway Regulation Of Metabolic Process Regulation Of Cytoplasmic Translation	RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Extracellular Vesicle MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Negative Regulation Of Extracellular Matrix Organization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Cardiac Epithelial To Mesenchymal Transition Regulation Of Gene Expression Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Macromolecule Biosynthetic Process Regulation Of Sprouting Angiogenesis Negative Regulation Of Inflammatory Response Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Translation Regulation Of Extracellular Matrix Organization Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Extracellular Matrix Assembly Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Bacterial Lipopeptide Response To Bacterial Lipoprotein Negative Regulation Of Fibroblast Migration Regulation Of Macromolecule Metabolic Process Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death MRNA Destabilization Negative Regulation Of Defense Response Extracellular Space RNA Destabilization Negative Regulation Of Protein Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Cell Migration Regulation Of Vasculature Development
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