GEMIN6 and STRAP

Number of citations of the paper that reports this interaction (PMID 15848170)
21

Data Source:
HPRD (in vitro)

		GEMIN6	STRAP
Gene Name		gem (nuclear organelle) associated protein 6	serine/threonine kinase receptor associated protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Nuclear Body SMN Complex SMN-Sm Protein Complex Gemini Of Coiled Bodies	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane SMN Complex SMN-Sm Protein Complex
	Molecular Function	Protein Binding	Receptor Binding Protein Binding Poly(A) RNA Binding
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Gene Expression NcRNA Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Spliceosomal SnRNP Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Pathways		snRNP Assembly Metabolism of non-coding RNA	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: GEMIN7 RN7SL1 RNU1-1 RNU2-1 SNRPB SNRPD2 SNRPD3 SNRPE SNRPF SNRPG STRAP TOX4	24 interactors: C6orf203 CHEK2 GEMIN6 GEMIN7 MAP1B NXF1 PBLD PDPK1 RN7SL1 RNU1-1 RNU2-1 SMAD2 SMAD3 SMAD6 SMAD7 SMN1 SMURF1 SNRPB SNRPD2 SNRPD3 SNRPE SUMO4 TGFBR1 TGFBR2
Entrez ID		79833	11171
HPRD ID		06110	05816
Ensembl ID			ENSG00000023734
Uniprot IDs		Q8WXD5	B0AZV0 B4DNJ6 Q9Y3F4
PDB IDs		1Y96
Enriched GO Terms of Interacting Partners?		Spliceosomal SnRNP Assembly Ribonucleoprotein Complex Assembly MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Ribonucleoprotein Complex Biogenesis RNA Splicing Histone MRNA Metabolic Process MRNA Processing MRNA Metabolic Process RNA Processing Termination Of RNA Polymerase II Transcription Cellular Macromolecular Complex Assembly DNA-templated Transcription, Termination NcRNA Metabolic Process MRNA 3'-end Processing RNA 3'-end Processing Cellular Component Assembly RNA Metabolic Process Spliceosomal Complex Assembly Gene Expression Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cellular Macromolecule Biosynthetic Process Maintenance Of Gastrointestinal Epithelium Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of Epithelial To Mesenchymal Transition Epithelial Structure Maintenance Negative Regulation Of Stem Cell Differentiation Negative Regulation Of Epithelial Cell Migration	Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Spliceosomal SnRNP Assembly Regulation Of Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway NcRNA Metabolic Process Ribonucleoprotein Complex Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta RNA Processing MRNA Splicing, Via Spliceosome Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway RNA Splicing, Via Transesterification Reactions Regulation Of Epithelial To Mesenchymal Transition Cellular Macromolecular Complex Assembly Cellular Component Assembly Ribonucleoprotein Complex Biogenesis RNA Splicing Cellular Response To Growth Factor Stimulus Response To Growth Factor Gene Expression MRNA Processing Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Signal Transduction Regulation Of Pathway-restricted SMAD Protein Phosphorylation Pathway-restricted SMAD Protein Phosphorylation RNA Metabolic Process Embryonic Cranial Skeleton Morphogenesis MRNA Metabolic Process Negative Regulation Of Signaling Spliceosomal Complex Assembly Enzyme Linked Receptor Protein Signaling Pathway Regulation Of BMP Signaling Pathway Histone MRNA Metabolic Process Response To Cholesterol Regulation Of Cell Morphogenesis Zygotic Specification Of Dorsal/ventral Axis Activin Receptor Signaling Pathway Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Embryonic Skeletal System Morphogenesis Mesonephros Development Kidney Development Termination Of RNA Polymerase II Transcription Negative Regulation Of Protein Phosphorylation Renal System Development Negative Regulation Of BMP Signaling Pathway
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