MCF2L and YAE1D1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MCF2L	YAE1D1
Gene Name		MCF.2 cell line derived transforming sequence-like	Yae1 domain containing 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Lamellipodium
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity 1-phosphatidylinositol Binding
	Biological Process	Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS		Factor VII ( 17903294) Osteoarthritis ( 21871595)
Protein-Protein Interactions		7 interactors: AIMP2 CDC42 RABAC1 RAC1 RHOA RHOG YAE1D1	17 interactors: APP BBS10 CHD3 CRMP1 HAUS5 HNRNPA2B1 KIAA1377 MCF2L METTL18 NACAD NAT14 ORAOV1 SERPINA4 SLC25A33 TPD52L1 VIM ZNF579
Entrez ID		23263	57002
HPRD ID		14371	16669
Ensembl ID		ENSG00000126217	ENSG00000241127
Uniprot IDs		G5E9A1 O15068	B4DE83 Q9NRH1
PDB IDs
Enriched GO Terms of Interacting Partners?		Axon Guidance Blood Coagulation Hemostasis Ephrin Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Projection Organization Regulation Of Cell Projection Assembly Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Wound Healing Chemotaxis Actin Cytoskeleton Organization Small GTPase Mediated Signal Transduction Neuron Projection Morphogenesis Actin Filament-based Process Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Wounding Cell Morphogenesis Involved In Differentiation Regulation Of Small GTPase Mediated Signal Transduction Platelet Activation Cell-cell Junction Organization Neuron Projection Development Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Cell Motility Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Neuron Development Positive Regulation Of Cell Projection Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Cell Morphogenesis Epithelium Development Positive Regulation Of Cellular Component Biogenesis Substantia Nigra Development Neuron Differentiation Cytoskeleton Organization Positive Regulation Of Cytokinesis Cell Projection Organization Positive Regulation Of Stress Fiber Assembly Locomotion Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphatidylinositol 3-kinase Activity Neural Nucleus Development Regulation Of Cytokinesis Regulation Of Lipid Kinase Activity Rho Protein Signal Transduction Cell Differentiation	Spindle Organization
Tagcloud ?		blocks brefeldin cdc42 cytoskeleton dbs defective dispersal edge encodes enlarged golgi guanine healing limits localized localizes mb microtubule motility osteoarthritis polarization reorient rhogef secretory transforming transport transwell vesicle wound
Tagcloud (Difference) ?		blocks brefeldin cdc42 cytoskeleton dbs defective dispersal edge encodes enlarged golgi guanine healing limits localized localizes mb microtubule motility osteoarthritis polarization reorient rhogef secretory transforming transport transwell vesicle wound
Tagcloud (Intersection) ?