MCF2L and YAE1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		MCF2L	YAE1
Description		MCF.2 cell line derived transforming sequence like	YAE1 maturation factor of ABCE1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Nucleus Cytoplasm
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Phosphatidylinositol Binding	Protein Binding
	Biological Process	Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction	Protein Maturation
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure ( 27841878) Factor VII ( 17903294) Mean platelet volume ( 32888494) Osteoarthritis ( 21871595) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878 28135244 30578418)
Interacting Genes		7 interacting genes: AIMP2 CDC42 RABAC1 RAC1 RHOA RHOG YAE1	18 interacting genes: APP BBS10 CEP126 CHD3 CRMP1 EXOC7 HAUS5 HNRNPA2B1 LTO1 MCF2L METTL18 NACAD NAT14 SERPINA4 SLC25A33 TPD52L1 VIM ZNF579
Entrez ID		23263	57002
HPRD ID		14371	16669
Ensembl ID		ENSG00000126217	ENSG00000241127
Uniprot IDs		H0Y4M6 O15068	Q9NRH1
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Stress Fiber Assembly Glutamatergic Synapse Membrane Invagination Non-canonical Wnt Signaling Pathway Postsynapse Actin Filament Organization Positive Regulation Of Actin Filament Bundle Assembly Small GTPase-mediated Signal Transduction G Protein Activity Regulation Of Synapse Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process GTPase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Stress Fiber Assembly Secretory Granule Membrane GTP Binding Actin Cytoskeleton Organization Thioesterase Binding Regulation Of Actin Filament-based Process Actin Filament-based Process Focal Adhesion Protein Kinase Binding Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynapse Organization Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Polarized Epithelial Cell Differentiation Cell-cell Junction Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Cytoskeleton Organization Rac Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Regulation Of Ruffle Assembly Phagocytosis, Engulfment Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Telencephalon Cell Migration Regulation Of Cell Junction Assembly
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