MCF2L

Description		MCF.2 cell line derived transforming sequence like
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Phosphatidylinositol Binding
	Biological Process	Positive Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure ( 27841878) Factor VII ( 17903294) Mean platelet volume ( 32888494) Osteoarthritis ( 21871595) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878 28135244 30578418)
Interacting Genes		7 interacting genes: AIMP2 CDC42 RABAC1 RAC1 RHOA RHOG YAE1
Entrez ID		23263
HPRD ID		14371
Ensembl ID		ENSG00000126217
Uniprot IDs		H0Y4M6 O15068
PDB IDs
Enriched GO Terms of Interacting Partners?		Establishment Or Maintenance Of Cell Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Stress Fiber Assembly Glutamatergic Synapse Membrane Invagination Non-canonical Wnt Signaling Pathway Postsynapse Actin Filament Organization Positive Regulation Of Actin Filament Bundle Assembly Small GTPase-mediated Signal Transduction G Protein Activity Regulation Of Synapse Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process GTPase Activity Regulation Of Actin Cytoskeleton Organization Regulation Of Stress Fiber Assembly Secretory Granule Membrane GTP Binding Actin Cytoskeleton Organization Thioesterase Binding Regulation Of Actin Filament-based Process Actin Filament-based Process Focal Adhesion Protein Kinase Binding Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynapse Organization Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Positive Regulation Of Supramolecular Fiber Organization Polarized Epithelial Cell Differentiation Cell-cell Junction Organization Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Positive Regulation Of Cytoskeleton Organization Rac Protein Signal Transduction Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Establishment Of Epithelial Cell Polarity Regulation Of Ruffle Assembly Phagocytosis, Engulfment Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Lamellipodium Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Telencephalon Cell Migration Regulation Of Cell Junction Assembly
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