C19orf57 and COPS4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		C19orf57	COPS4
Gene Name		chromosome 19 open reading frame 57	COP9 signalosome subunit 4
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component	Nucleus Nucleoplasm Synaptic Vesicle COP9 Signalosome Cell Junction Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein Binding	Protein Binding
	Biological Process	Multicellular Organismal Development	Protein Deneddylation Cullin Deneddylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		24 interactors: AIMP2 APP C19orf25 CENPQ COPS4 CTNNAL1 EWSR1 FAM9B FBXO25 GPS2 HAUS3 HOMER1 IKBKG KRT38 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 PSMA6 RABL6 RUNX1T1 TRIM23 TSC22D3 VCL	17 interactors: C19orf57 CCDC85B COPS2 COPS3 COPS5 COPS6 COPS7A COPS8 CUL5 FOS IKBKB JUN MBIP RCBTB2 TP53 USHBP1 YWHAQ
Entrez ID		79173	51138
HPRD ID		14415	09888
Ensembl ID		ENSG00000132016	ENSG00000138663
Uniprot IDs		Q0VDD7	B3KM48 Q9BT78
PDB IDs
Enriched GO Terms of Interacting Partners?			Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Apoptotic Signaling Pathway Cellular Protein Modification Process Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Intracellular Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Regulation Of Signal Transduction Response To Radiation Transcription From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Innate Immune Response Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Cellular Response To Extracellular Stimulus Regulation Of Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Fc-epsilon Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Cellular Response To Calcium Ion Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Myeloid Leukocyte Differentiation Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Innate Immune Response Response To Growth Factor Negative Regulation Of Nucleic Acid-templated Transcription SMAD Protein Signal Transduction Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Mitochondrion Organization
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