HLA-A and LILRB2

Number of citations of the paper that reports this interaction (PMID 12853576)
72

Data Source:
HPRD (in vitro)

		HLA-A	LILRB2
Gene Name		major histocompatibility complex, class I, A	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Golgi Medial Cisterna Plasma Membrane Integral Component Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Phagocytic Vesicle Membrane Early Endosome Membrane MHC Class I Protein Complex Extracellular Vesicular Exosome Endoplasmic Reticulum Exit Site Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Receptor Binding Protein Binding Beta-2-microglobulin Binding Peptide Antigen Binding T Cell Receptor Binding Poly(A) RNA Binding TAP Binding	Receptor Activity Protein Binding Protein Phosphatase 1 Binding MHC Class Ib Protein Binding Inhibitory MHC Class I Receptor Activity MHC Class I Protein Binding Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Immune Response Viral Process Detection Of Bacterium Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Protection From Natural Killer Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Memory T Cell Activation	Negative Regulation Of Antigen Processing And Presentation Positive Regulation Of T Cell Tolerance Induction Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Inhibitory Signaling Pathway Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Immune Response Negative Regulation Of Calcium Ion Transport Cellular Response To Lipopolysaccharide Regulation Of Dendritic Cell Differentiation
Pathways		Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System Interferon gamma signaling Interferon Signaling Endosomal/Vacuolar pathway Cytokine Signaling in Immune system Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen processing-Cross presentation ER-Phagosome pathway Adaptive Immune System	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Adverse response to carbamapezine ( 21149285) Beta-2 microglubulin plasma levels ( 23417110) Complement C3 and C4 levels ( 23028341) Crohn's disease ( 22412388) Drug-induced liver injury (amoxicillin-clavulanate) ( 21570397) HIV-1 control ( 20041166) IgA nephropathy ( 22197929) IgE levels ( 22075330) Nasopharyngeal carcinoma ( 19664746 20512145) Vitiligo ( 20410501)	HDL cholesterol ( 20686565)
Protein-Protein Interactions		25 interactors: APLP2 B2M BCAP31 CALR CANX CD8A DEK DERL1 ERBB2 KIR3DL2 LILRB1 LILRB2 MAGEA1 MAGEA4 MEOX2 PDIA3 PRKAR1A PRKCA SRC STAT3 TAPBP TRA TRB UBB ZDHHC17	7 interactors: FCGR1A HLA-A HLA-B HLA-C HLA-F HLA-G PTPN6
Entrez ID		3105	10288
HPRD ID		00826	11994
Ensembl ID		ENSG00000206503	ENSG00000131042
Uniprot IDs		B1PKY1 B2R7U3 P04439 P30443 Q5SUL5	A2IXV5 A8MU67 C9JF29 Q8N423
PDB IDs		1W72 2XPG 3BO8 3RL1 3RL2	2DYP 2GW5 4LLA
Enriched GO Terms of Interacting Partners?		Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Immune System Process Antigen Processing And Presentation Of Peptide Antigen Defense Response Neurotrophin TRK Receptor Signaling Pathway Signaling Neurotrophin Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cell Communication Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Immune Response Regulation Of Immune System Process Signal Transduction Homeostatic Process Cellular Response To Organic Substance Response To Stress Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Chemical Homeostasis Regulation Of Immune Response Regulation Of Signaling Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Positive Regulation Of Cell Adhesion Positive Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signal Transduction Response To Stimulus Regulation Of Protein Kinase Activity Fc Receptor Mediated Inhibitory Signaling Pathway Cellular Response To Stimulus Regulation Of Kinase Activity Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Viral Process Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Immune Response-inhibiting Signal Transduction Response To Growth Factor Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Dendritic Cell Differentiation Negative Regulation Of T Cell Proliferation Protein Transport	Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-independent Response To Interferon-gamma Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Response To Type I Interferon Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of T Cell Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of T Cell Mediated Cytotoxicity Regulation Of Adaptive Immune Response Positive Regulation Of Leukocyte Mediated Cytotoxicity Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Killing Positive Regulation Of T Cell Mediated Immunity Regulation Of Leukocyte Mediated Cytotoxicity Antigen Processing And Presentation Of Peptide Antigen Cellular Response To Cytokine Stimulus Antigen Processing And Presentation Positive Regulation Of Immune Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Response To Cytokine Positive Regulation Of Adaptive Immune Response Innate Immune Response Regulation Of Immune Response Positive Regulation Of Immune System Process Immune Response Regulation Of Immune System Process Defense Response Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Endogenous Antigen Cellular Response To Organic Substance Immune System Process Response To Organic Substance Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Surface Receptor Signaling Pathway Response To Stress Negative Regulation Of Immune System Process Regulation Of Dendritic Cell Differentiation Negative Regulation Of Immune Response Detection Of Bacterium Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Signal Transduction Detection Of Biotic Stimulus
Tagcloud ?			abilities acetylcholine adrenergic alpha7 alpha7nachr ars bindings characters deterioration drivers eph exact fcgamma fcgammariib immunoglobulin ltp neurotrophin nicotinic oligomeric ortholog p75ntr pirb presumed prion prpc rescuing spine summarizes synapse
Tagcloud (Difference) ?			abilities acetylcholine adrenergic alpha7 alpha7nachr ars bindings characters deterioration drivers eph exact fcgamma fcgammariib immunoglobulin ltp neurotrophin nicotinic oligomeric ortholog p75ntr pirb presumed prion prpc rescuing spine summarizes synapse
Tagcloud (Intersection) ?