ALG12 and PRDX4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ALG12	PRDX4
Gene Name		ALG12, alpha-1,6-mannosyltransferase	peroxiredoxin 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Extracellular Space Nucleus Mitochondrion Smooth Endoplasmic Reticulum Cytosol Extracellular Vesicular Exosome
	Molecular Function	Alpha-1,6-mannosyltransferase Activity Mannosyltransferase Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity	Protein Binding Thioredoxin Peroxidase Activity Protein Homodimerization Activity
	Biological Process	Protein Folding Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Mannosylation	I-kappaB Phosphorylation Spermatogenesis Male Gonad Development 4-hydroxyproline Metabolic Process Protein Maturation By Protein Folding Extracellular Matrix Organization Cell Redox Homeostasis Oxidation-reduction Process Reactive Oxygen Species Metabolic Process Negative Regulation Of Male Germ Cell Proliferation
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: PRDX4 RPL13A	24 interactors: A1BG ALG12 APOB CFHR1 CFHR3 CLIC1 COX1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 NR4A1 PLG PRDX1 PRDX2 PRDX3 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 VTN
Entrez ID		79087	10549
HPRD ID		06189	05935
Ensembl ID			ENSG00000123131
Uniprot IDs		Q9BV10	Q13162
PDB IDs			2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Formation Of Translation Preinitiation Complex Negative Regulation Of Male Germ Cell Proliferation Regulation Of Male Germ Cell Proliferation Protein Maturation By Protein Folding I-kappaB Phosphorylation Negative Regulation Of Translational Initiation 4-hydroxyproline Metabolic Process	Hydrogen Peroxide Catabolic Process Cellular Response To Reactive Oxygen Species Response To Stress Hydrogen Peroxide Metabolic Process Immune System Process Response To Reactive Oxygen Species Cellular Response To Oxidative Stress Response To Oxidative Stress Response To Inorganic Substance Catabolic Process Reactive Oxygen Species Metabolic Process Defense Response Removal Of Superoxide Radicals Response To Lipopolysaccharide Cellular Response To Superoxide Response To Molecule Of Bacterial Origin Xenobiotic Metabolic Process Negative Regulation Of Proteolysis Cellular Response To Xenobiotic Stimulus Response To Superoxide Response To Oxygen Radical Regulation Of Proteolysis Response To Xenobiotic Stimulus Negative Regulation Of Protein Processing Regulation Of Mitochondrial Membrane Potential Regulation Of Protein Processing Response To Stimulus Bile Acid Metabolic Process Blood Coagulation Hemostasis Superoxide Metabolic Process Platelet Activation Innate Immune Response Cell Migration Positive Regulation Of Wound Healing Response To Lipid Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Thromboxane A2 Signaling Pathway Hsp90 Deacetylation Immune Response Response To Bacterium Carbohydrate Derivative Transport Leukocyte Migration Negative Regulation Of Blood Coagulation Cell Motility Negative Regulation Of Coagulation Steroid Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Wound Healing Regulation Of Body Fluid Levels
Tagcloud ?		bones cardiomyopathy cdg cdgs dislocations dolichol dysplasia dysplasias equinovarus exome frameshifts glycosylation hypoplasia ig infant knees neurodevelopmental oligosaccharides ossification platyspondyly pseudodiastrophic pubic resembles rhizomelic stature talipes underossification undiagnosed vertebrae	1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Difference) ?		bones cardiomyopathy cdg cdgs dislocations dolichol dysplasia dysplasias equinovarus exome frameshifts glycosylation hypoplasia ig infant knees neurodevelopmental oligosaccharides ossification platyspondyly pseudodiastrophic pubic resembles rhizomelic stature talipes underossification undiagnosed vertebrae	1e accomplished antioxidative byproduct disulfide folding glutamine h2o2 hyperoxidation imbalance ins isomerase metabolized negligibly nutrient overwhelm oxidoreductin peroxidase peroxide peroxiredoxin prediabetic proinsulin reoxidizing secretagogue secretagogues secreting stoichiometric takes utilize
Tagcloud (Intersection) ?