ALG12 and RPL13A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ALG12	RPL13A
Description		ALG12 alpha-1,6-mannosyltransferase	ribosomal protein L13a
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane	Nucleus Nucleolus Cytoplasm Cytosol Ribosome Focal Adhesion Large Ribosomal Subunit Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse GAIT Complex Ribonucleoprotein Complex
	Molecular Function	Alpha-1,6-mannosyltransferase Activity Mannosyltransferase Activity Transferase Activity Glycosyltransferase Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity	RNA Binding MRNA Binding Structural Constituent Of Ribosome
	Biological Process	Protein Folding Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process	Cytoplasmic Translation Translation Regulation Of Translation Negative Regulation Of Translation Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Homeostatic Process Macrophage Chemotaxis Lung Morphogenesis Cellular Response To Type II Interferon Negative Regulation Of Formation Of Translation Preinitiation Complex
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG12 causes CDG-1g	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs			(S)-3-phenyllactic acid Anisomycin Puromycin
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Acne (severe) ( 24927181) Platelet count ( 32888494) Platelet distribution width ( 32888494)	Hematological and biochemical traits ( 20139978) Monocyte count ( 32888494)
Interacting Genes		2 interacting genes: PRDX4 RPL13A	15 interacting genes: ALDH2 ALG12 CALM1 CRP CYP2E1 ETS1 FBH1 FILNC1 FNTA GOLM1 MT-ND1 NOD2 PTEN STOM VTN
Entrez ID		79087	23521
HPRD ID		06189	11775
Ensembl ID		ENSG00000182858	ENSG00000142541
Uniprot IDs		Q9BV10	A0A384ME37 P40429 Q8J015
PDB IDs			4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Regulation Of Germ Cell Proliferation I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Thioredoxin Peroxidase Activity Regulation Of Male Germ Cell Proliferation Negative Regulation Of Formation Of Translation Preinitiation Complex GAIT Complex Negative Regulation Of Cytoplasmic Translational Initiation Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Hydrogen Peroxide Catabolic Process Molecular Sequestering Activity Large Ribosomal Subunit Macrophage Chemotaxis Macrophage Migration Antioxidant Activity Positive Regulation Of Natural Killer Cell Activation Lung Morphogenesis Peroxidase Activity Hydrogen Peroxide Metabolic Process Regulation Of Cytoplasmic Translation Cell Redox Homeostasis Regulation Of Natural Killer Cell Activation Homeostatic Process Negative Regulation Of Translational Initiation Cytosolic Large Ribosomal Subunit Negative Regulation Of Reproductive Process Cellular Response To Type II Interferon Cellular Oxidant Detoxification Regulation Of Cell Population Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?