ALG12

Description		ALG12 alpha-1,6-mannosyltransferase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Alpha-1,6-mannosyltransferase Activity Mannosyltransferase Activity Transferase Activity Glycosyltransferase Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity
	Biological Process	Protein Folding Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process
Pathways		Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG12 causes CDG-1g
Drugs
Diseases		Congenital disorders of glycosylation (CDG) type I
GWAS		Acne (severe) ( 24927181) Platelet count ( 32888494) Platelet distribution width ( 32888494)
Interacting Genes		2 interacting genes: PRDX4 RPL13A
Entrez ID		79087
HPRD ID		06189
Ensembl ID		ENSG00000182858
Uniprot IDs		Q9BV10
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Germ Cell Proliferation I-kappaB Phosphorylation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Negative Regulation Of Male Germ Cell Proliferation Thioredoxin Peroxidase Activity Regulation Of Male Germ Cell Proliferation Negative Regulation Of Formation Of Translation Preinitiation Complex GAIT Complex Negative Regulation Of Cytoplasmic Translational Initiation Positive Regulation Of Natural Killer Cell Proliferation Regulation Of Natural Killer Cell Proliferation Hydrogen Peroxide Catabolic Process Molecular Sequestering Activity Large Ribosomal Subunit Macrophage Chemotaxis Macrophage Migration Antioxidant Activity Positive Regulation Of Natural Killer Cell Activation Lung Morphogenesis Peroxidase Activity Hydrogen Peroxide Metabolic Process Regulation Of Cytoplasmic Translation Cell Redox Homeostasis Regulation Of Natural Killer Cell Activation Homeostatic Process Negative Regulation Of Translational Initiation Cytosolic Large Ribosomal Subunit Negative Regulation Of Reproductive Process Cellular Response To Type II Interferon Cellular Oxidant Detoxification Regulation Of Cell Population Proliferation
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