SLBP and NSD2

		SLBP	NSD2
Description		stem-loop histone mRNA binding protein	nuclear receptor binding SET domain protein 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Histone MRNA Stem-loop Binding Complex Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm
	Molecular Function	RNA Binding MRNA Binding Protein Binding Identical Protein Binding Histone Pre-mRNA Stem-loop Binding Histone Pre-mRNA DCP Binding	DNA Binding Chromatin Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Histone H4K20 Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Histone H3K36 Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K36 Trimethyltransferase Activity
	Biological Process	Cap-dependent Translational Initiation MRNA Processing MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Transport	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases			Multiple myeloma
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 25673412 34021172) Hip index ( 34021172) Hip minimal joint space width ( 27701424) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		12 interacting genes: CDK1 CDK2 CDK4 CDK6 CEBPA CSNK2A1 DCAF11 ERI1 LSM10 PTGER4 USP8 ZNF473	15 interacting genes: AGO2 APP AR AURKA BRCA1 ESR1 H19 H3-4 H3C1 H3C14 HORMAD2 MDC1 PCNA PLEKHF2 TP53
Entrez ID		7884	7468
HPRD ID		03884	04259
Ensembl ID		ENSG00000163950	ENSG00000109685
Uniprot IDs		B3KSC5 B3KST9 B4DUW7 E7EUV9 Q14493 Q53XR2	O96028
PDB IDs		2KJM 4L8R 4QOZ	5LSU 5VC8 6UE6 6XCG 7CRO 7E8D 7LMT 7MDN 7VLN 9EXW 9EXX 9EXY 9GBF
Enriched GO Terms of Interacting Partners?		Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Histone MRNA Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Cell Cycle Phase Transition Regulation Of Cell Cycle Histone Kinase Activity MRNA 3'-end Processing By Stem-loop Binding And Cleavage Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Process Cajal Body Response To Ketone Cellular Response To Oxygen-containing Compound Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Protein Kinase Activity RNA 3'-end Processing Regulation Of Macromolecule Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Metabolic Process DNA Damage Checkpoint Signaling Kinase Activity Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Hemopoiesis Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Nucleoplasm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Protein Localization To Site Of Double-strand Break Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Signal Transduction In Response To DNA Damage Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Damage Response	Chromatin Organization Nucleoplasm Enzyme Binding Chromatin Remodeling Chromatin Binding Regulation Of MiRNA Transcription Protein Heterodimerization Activity Regulation Of MiRNA Metabolic Process Molecular Function Activator Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Developmental Growth Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Regulation Of Reproductive Process Prostate Gland Growth Nuclear Body Mitotic DNA Damage Checkpoint Signaling Protein-DNA Complex Assembly Estrogen Response Element Binding Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Biosynthetic Process Chromosome Positive Regulation Of Reproductive Process Nucleus Macromolecule Metabolic Process Structural Constituent Of Chromatin Protein-containing Complex Cellular Response To Estrogen Stimulus Mammary Gland Alveolus Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Core Promoter Sequence-specific DNA Binding Nucleic Acid Metabolic Process DNA Damage Checkpoint Signaling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Nucleosome Assembly DNA Binding Regulation Of Cellular Response To Stress Gene Expression Prostate Gland Epithelium Morphogenesis Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Cellular Response To Oxygen-containing Compound Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II
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