ABI3BP and FZD5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ABI3BP	FZD5
Description		ABI family member 3 binding protein	frizzled class receptor 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix	Golgi Membrane Early Endosome Golgi Apparatus Plasma Membrane Bicellular Tight Junction Cell Surface Membrane Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Early Endosome Membrane Cell Projection Perikaryon Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Extracellular Matrix Structural Constituent	Amyloid-beta Binding Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Lipid Binding Wnt-protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Wnt Receptor Activity Protein-containing Complex Binding
	Biological Process	Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization	Embryonic Axis Specification Angiogenesis Eye Development Vasculature Development Glandular Epithelial Cell Maturation Positive Regulation Of T Cell Cytokine Production Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Synapse Assembly Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Wnt Signaling Pathway Neuron Differentiation Embryonic Camera-type Eye Development Post-embryonic Camera-type Eye Development Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production T Cell Differentiation In Thymus Non-canonical Wnt Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis System Development Spemann Organizer Formation Canonical Wnt Signaling Pathway Apoptotic Process Involved In Morphogenesis Intestinal Epithelial Cell Maturation Branching Involved In Labyrinthine Layer Morphogenesis Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Labyrinthine Layer Blood Vessel Development Chorionic Trophoblast Cell Differentiation Cellular Response To Molecule Of Bacterial Origin Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Mitophagy Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Bicellular Tight Junction Assembly
Pathways			Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Signaling by RNF43 mutants
Drugs
Diseases
GWAS		Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced) ( 24236485) Alcohol dependence ( 26365420) Asthma (childhood onset) ( 23829686) Carotid plaque burden ( 28282560) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Joint mobility (Beighton score) ( 27182965) Multiple sclerosis ( 31604244) Optic disc area ( 25631615 28073927) Optic disc size ( 31809533) Post bronchodilator FEV1 in COPD ( 26634245) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Hematocrit ( 32888494) Hemoglobin ( 32888494)
Interacting Genes		6 interacting genes: ABI3 CBX1 FZD5 GOT1 GRB2 MBNL1	13 interacting genes: ABI3BP GOPC GSK3B LRP6 LZTFL1 RGS2 ROR2 RPS6KA6 SLC22A2 SLC35B1 UBTD1 WNT5A WNT7A
Entrez ID		25890	7855
HPRD ID		09380	03427
Ensembl ID		ENSG00000154175	ENSG00000163251
Uniprot IDs		D3YTG3 F6R962 H7C556 Q7Z7G0	Q13467
PDB IDs			5URY 5URZ 6O39 6WW2
Enriched GO Terms of Interacting Partners?		Branching Involved In Labyrinthine Layer Morphogenesis L-cysteine Transaminase Activity L-glutamate Catabolic Process To Aspartate L-aspartate:2-oxoglutarate Aminotransferase Activity Aspartate Biosynthetic Process Phosphatidylserine Decarboxylase Activity L-glutamate Biosynthetic Process Embryonic Morphogenesis Guanyl-nucleotide Exchange Factor Adaptor Activity Anatomical Structure Morphogenesis Grb2-EGFR Complex Oxaloacetate Metabolic Process Transdifferentiation Carboxylic Acid Binding L-aspartate Catabolic Process Glutamate Biosynthetic Process L-glutamate Catabolic Process Malate-aspartate Shuttle Response To Transition Metal Nanoparticle Glycerol Biosynthetic Process Negative Regulation Of Mitochondrial Depolarization Aspartate Metabolic Process Morphogenesis Of A Branching Structure Morphogenesis Of A Branching Epithelium Regulation Of Lymphocyte Mediated Immunity Neurotrophin TRKA Receptor Binding Chorionic Trophoblast Cell Differentiation Regulation Of Chorionic Trophoblast Cell Proliferation Intestinal Epithelial Cell Maturation Glandular Epithelial Cell Maturation Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Spemann Organizer Formation Post-embryonic Camera-type Eye Development Male Pronucleus Actin-based Cell Projection Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Ruffle Assembly Regulation Of Cell Junction Assembly Anterior/posterior Axis Specification, Embryo Columnar/cuboidal Epithelial Cell Maturation Synapse Organization Female Pronucleus Defense Response To Tumor Cell Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Cytosolic Calcium Ion Concentration Glycerol Metabolic Process Cell Differentiation Morphogenesis Of An Epithelium Insulin Receptor Substrate Binding Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity	Canonical Wnt Signaling Pathway Postsynapse Assembly Wnt Signaling Pathway Frizzled Binding Positive Regulation Of Protein Localization To Synapse Toxin Transmembrane Transporter Activity Regulation Of Neuron Projection Development Wnt Signalosome Regulation Of Protein Localization To Cilium Epithelial To Mesenchymal Transition Midbrain Dopaminergic Neuron Differentiation Excitatory Synapse Assembly Secondary Palate Development Presynapse Assembly Establishment Of Cell Polarity Negative Regulation Of Developmental Process Mesenchymal Cell Differentiation Presynapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade Regulation Of Cell Projection Organization Uterus Development Positive Regulation Of Cell Projection Organization Central Nervous System Neuron Differentiation Regulation Of Axonogenesis Regulation Of JNK Cascade Regulation Of Protein Localization To Synapse Wnt-protein Binding Positive Regulation Of Neuron Projection Development Establishment Or Maintenance Of Cell Polarity Embryonic Axis Specification Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Lipid Midbrain Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Dopaminergic Neuron Differentiation Cellular Response To Lipid Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Neuron Projection Organization Regulation Of Protein Localization Postsynapse Organization Presynapse Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Localization Regulation Of Microtubule Anchoring At Centrosome Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Receptor Tyrosine Kinase-like Orphan Receptor Binding Chemoattraction Of Serotonergic Neuron Axon
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