SLC30A3 and SGPL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC30A3	SGPL1
Description		solute carrier family 30 member 3	sphingosine-1-phosphate lyase 1
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Plasma Membrane Synaptic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Neuron Projection Synapse Hippocampal Mossy Fiber Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Microvesicle	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Zinc Ion Transmembrane Transporter Activity Protein Binding Monoatomic Cation Transmembrane Transporter Activity Antiporter Activity Metal Ion Binding	Protein Binding Sphinganine-1-phosphate Aldolase Activity Lyase Activity Carbon-carbon Lyase Activity Pyridoxal Phosphate Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Cation Transport Zinc Ion Transport Response To Zinc Ion Positive Regulation Of Transport Transmembrane Transport Zinc Ion Import Into Organelle Zinc Ion Transmembrane Transport Zinc Ion Import Into Synaptic Vesicle Zinc Ion Import Into Lysosome	Luteinization Vasculogenesis Kidney Development Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Apoptotic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Fibroblast Migration Carboxylic Acid Metabolic Process Hemopoiesis Sphingolipid Catabolic Process Leydig Cell Differentiation Regulation Of Multicellular Organism Growth Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Roof Of Mouth Development Face Morphogenesis Apoptotic Signaling Pathway
Pathways		Zinc efflux and compartmentalization by the SLC30 family	Sphingolipid catabolism
Drugs			Pyridoxal phosphate
Diseases
GWAS		Metabolite levels ( 23823483)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Metabolite levels ( 23823483) Microalbuminuria ( 26631737) Red cell distribution width ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		33 interacting genes: AP3B1 AP3D1 AP3S1 AQP6 CD40 CD79A CGRRF1 CYB5R3 DNAJC5 ELOVL4 FCRL3 FKBP7 GJA8 GOLM1 GPR152 GPR42 GPX8 HSD17B13 LMNA NAALADL2 RETREG3 RNF19B RTN3 SAR1A SCN3B SGPL1 SLC10A6 SLC18A1 SLC30A8 SLC34A2 SLC35H1 TMEM14B TMEM242	34 interacting genes: AQP3 AQP9 BCL2L2 BRICD5 CCL4L2 CLDN19 EFNA5 ERG28 FA2H FAM177A1 FXYD3 HMOX2 IFITM3 MARCHF5 MFSD6 MIP MMD2 PAQR5 PLP2 PLPP4 RNASE10 RTP2 SCAMP5 SLC30A3 SRPK2 STATH STING1 STX4 STX8 TMEM176A TMEM242 TMEM97 TSPAN4 UNC50
Entrez ID		7781	8879
HPRD ID		11924	07224
Ensembl ID		ENSG00000115194	ENSG00000166224
Uniprot IDs		B4DXX8 Q99726	A0A8V8TN35 O95470
PDB IDs		8XN1	4Q6R 8AYF
Enriched GO Terms of Interacting Partners?		Membrane Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Vesicle Cargo Loading AP-3 Adaptor Complex Anterograde Synaptic Vesicle Transport Melanosome Assembly Platelet Dense Granule Organization Membrane Coat Positive Regulation Of NK T Cell Differentiation Synaptic Vesicle Transport Synaptic Vesicle Coating Vesicle Coating Melanosome Organization Pigment Granule Organization Antigen Processing And Presentation, Exogenous Lipid Antigen Via MHC Class Ib Regulation Of NK T Cell Differentiation Anterograde Axonal Transport Endoplasmic Reticulum Vesicle Transport Along Microtubule Zinc Ion Import Into Organelle Vesicle Cytoskeletal Trafficking Transmembrane Transport Axon Cytoplasm Axonal Transport Secretory Granule Organization Protein Binding Synaptic Vesicle Recycling Axo-dendritic Transport Golgi To Vacuole Transport Organelle Transport Along Microtubule Endoplasmic Reticulum Membrane Endoplasmic Reticulum Tubular Network Organization Inorganic Cation Transmembrane Transport Presynapse Establishment Of Vesicle Localization Zinc Ion Transmembrane Transport Zinc Ion Transport Monoatomic Ion Transport Vesicle Localization Intracellular Zinc Ion Homeostasis Establishment Of Organelle Localization Nitrate Transmembrane Transporter Activity Inorganic Ion Transmembrane Transport Sphinganine-1-phosphate Aldolase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport	Membrane Channel Activity Water Channel Activity Water Transport Plasma Membrane Glycerol Channel Activity Fluid Transport Urea Transmembrane Transporter Activity Glycerol Transmembrane Transport Basolateral Plasma Membrane Polyol Transmembrane Transport Urea Transmembrane Transport R-loop Processing Positive Regulation Of CGAS/STING Signaling Pathway Urea Transport
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