PTTG1IP and PTTG1

Number of citations of the paper that reports this interaction (PMID 10781616)
12

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PTTG1IP	PTTG1
Gene Name		pituitary tumor-transforming 1 interacting protein	pituitary tumor-transforming 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	Molecular_function Receptor Activity	Sequence-specific DNA Binding Transcription Factor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding
	Biological Process	Protein Import Into Nucleus Multicellular Organismal Development	Mitotic Cell Cycle DNA Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Chromosome Segregation Mitotic Nuclear Division Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Chromosome Organization Cell Division
Pathways			APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC/C:Cdc20 mediated degradation of mitotic proteins Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins
Drugs
Diseases
GWAS			Insulin-related traits ( 22791750) Systemic lupus erythematosus ( 21408207)
Protein-Protein Interactions		4 interactors: CLEC7A LDLRAD1 PTTG1 RAB4A	15 interactors: ANAPC11 AURKA CAMK2A CDC20 CDC27 CDK1 CUL1 DNAJA1 FZR1 PPP2R5A PTTG1IP RPS10 TP53 UBE4A XRCC6
Entrez ID		754	9232
HPRD ID		04807	04998
Ensembl ID		ENSG00000183255	ENSG00000164611
Uniprot IDs		A8MZH8 B4DPZ0 P53801	O95997 Q6IAL9
PDB IDs
Enriched GO Terms of Interacting Partners?			Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Mitotic Cell Cycle Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Modification-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cell Cycle Process Cell Cycle Checkpoint Negative Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Negative Regulation Of Transferase Activity Cell Cycle Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Cell Division Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Catabolic Process Regulation Of Cell Cycle Process Protein K11-linked Ubiquitination Regulation Of Cell Division
Tagcloud ?		coimmunoprecipitation demonstrating e3 enhancing evident infrequently instability integrity ligase ligation maintaining mgmt pbf precise protooncogene proximity rad51 rad6 repertoire repressed represses thyrocytes thyroid transactivation transgenic tumorigenesis ubiquitination xrcc3	coimmunoprecipitation colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside pbf periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley
Tagcloud (Difference) ?		demonstrating e3 enhancing evident infrequently instability integrity ligase ligation maintaining mgmt precise protooncogene proximity rad51 rad6 repertoire repressed represses thyrocytes thyroid transactivation transgenic tumorigenesis ubiquitination xrcc3	colorectal critically delta126 eliciting emphasizing emvi extramural g245d gi gst hct116 i255f inc indicator interfered m133k outside periodicals poorer pull r273c sfn transferase ubiquitinated uncharacterised v197e wiley
Tagcloud (Intersection) ?		coimmunoprecipitation pbf