PTTG1IP and PTTG1

Number of citations: 0 (PubMedID 10781616)
Data Source: HPRD (in vitro, in vivo, two hybrid)

		PTTG1IP	PTTG1
Name		PTTG1 interacting protein	PTTG1 regulator of sister chromatid separation, securin
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	P53 Binding Protein Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding Molecular Function Activator Activity
	Biological Process	Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	DNA Repair DNA Damage Response Chromosome Segregation Spermatogenesis Homologous Chromosome Segregation Chromosome Organization Cell Division
Pathways		None	APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids
GWAS		Ankylosing spondylitis ( 30946743 ) Apolipoprotein A1 levels ( 32203549 ) Delirium ( 29631748 ) Gamma glutamyl transferase levels ( 29403010 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 33339817 29403010 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Mean corpuscular hemoglobin ( 32888494 27863252 ) Mean corpuscular volume ( 32888494 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red cell distribution width ( 32888494 28957414 )	Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Insulin-related traits ( 22791750 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 19838195 21408207 28714469 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 )
Interacting Genes		11 interacting genes: AMIGO1 ATP6AP2 CLEC7A LDLRAD1 PTTG1 RAB4A SGCB SLC22A23 TMEM106C TMPRSS2 TNFSF14	29 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC4 AURKA CAMK2A CDC20 CDC27 CDC34 CDH1 CDK1 CFTR CRK CUL1 DNAJA1 FZR1 KEAP1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2N UBE4A UBR5 XRCC6 ZFAND5
Entrez ID		754	9232
HPRD ID		04807	04998
Ensembl ID		ENSG00000183255	ENSG00000164611
Uniprot IDs		B4DPZ0 P53801	O95997 Q6IAL9
PDB IDs		Not available	7NJ0 7NJ1
GO Terms Enriched among Interactors		None	Proteasomal Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Anaphase-promoting Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Protein Ubiquitination Protein Branched Polyubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Meiotic Cell Cycle Macromolecule Catabolic Process Regulation Of Chromosome Segregation Proteolysis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Regulation Of Cell Cycle Process Catabolic Process Cell Division Cytosol Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Protein Metabolic Process Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Response To Oxidative Stress Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Protein-containing Complex Ubiquitin-protein Transferase Activator Activity Regulation Of Cell Cycle Phase Transition Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Cullin-RING Ubiquitin Ligase Complex