PTTG1IP and TNFSF14

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PTTG1IP	TNFSF14
Name		PTTG1 interacting protein	TNF superfamily member 14
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane
	Molecular Function	P53 Binding Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Apoptotic Process Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway T Cell Chemotaxis Positive Regulation Of T Cell Chemotaxis Signaling T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Myoblast Fusion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		None	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
GWAS		Ankylosing spondylitis ( 30946743 ) Apolipoprotein A1 levels ( 32203549 ) Delirium ( 29631748 ) Gamma glutamyl transferase levels ( 29403010 ) HDL cholesterol ( 30275531 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) High density lipoprotein cholesterol levels ( 33339817 29403010 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Mean corpuscular hemoglobin ( 32888494 27863252 ) Mean corpuscular volume ( 32888494 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Red cell distribution width ( 32888494 28957414 )	Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Granulocyte percentage of myeloid white cells ( 27863252 ) Monocyte count ( 29403010 ) Monocyte percentage of white cells ( 27863252 ) Multiple sclerosis ( 21833088 24076602 31604244 )
Interacting Genes		11 interacting genes: AMIGO1 ATP6AP2 CLEC7A LDLRAD1 PTTG1 RAB4A SGCB SLC22A23 TMEM106C TMPRSS2 TNFSF14	22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2
Entrez ID		754	8740
HPRD ID		04807	05157
Ensembl ID		ENSG00000183255	ENSG00000125735
Uniprot IDs		B4DPZ0 P53801	O43557
PDB IDs		Not available	4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU 7MSG
GO Terms Enriched among Interactors		None	Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Membrane Regulation Of Apoptotic Signaling Pathway Positive Regulation Of CAMP/PKA Signal Transduction Cytokine Activity Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules