XDH and GRIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		XDH	GRIP1
Description		xanthine dehydrogenase	glutamate receptor interacting protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Peroxisome Cytosol Sarcoplasmic Reticulum	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Endomembrane System Postsynaptic Density Membrane Dendrite Cytoplasmic Vesicle Cell Projection Neuron Projection Perikaryon Synapse Postsynaptic Membrane
	Molecular Function	Xanthine Dehydrogenase Activity Xanthine Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Molybdopterin Cofactor Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding Hypoxanthine Dehydrogenase Activity Hypoxanthine Oxidase Activity FAD Binding	Protein Binding Beta-catenin Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Allantoin Metabolic Process Guanine Catabolic Process Inosine Catabolic Process Deoxyinosine Catabolic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Deoxyguanosine Catabolic Process AMP Catabolic Process IMP Catabolic Process Lactation Hypoxanthine Catabolic Process Xanthine Catabolic Process Iron-sulfur Cluster Assembly Regulation Of Epithelial Cell Differentiation Amide Catabolic Process GMP Catabolic Process DGMP Catabolic Process DAMP Catabolic Process	Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization
Pathways		Purine catabolism Butyrophilin (BTN) family interactions Azathioprine ADME	Trafficking of GluR2-containing AMPA receptors
Drugs		Allopurinol Levocarnitine Topiroxostat Flavin adenine dinucleotide Dioxo(sulfanyl)molybdenum Eniluracil Niraxostat Febuxostat Oxypurinol
Diseases		Xanthinuria
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Male-pattern baldness ( 28196072) Multiple system atrophy ( 27629089) Obesity-related traits ( 23251661) Parahippocampal gyrus volume ( 31530798) Periventricular white matter hyperintensities ( 32517579) Zinc levels ( 26025379)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		2 interacting genes: BTN1A1 GRIP1	46 interacting genes: AGAP2 AR BAG4 CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII FXR1 FXR2 GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 KMT5B MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH
Entrez ID		7498	23426
HPRD ID		06363	19086
Ensembl ID		ENSG00000158125	ENSG00000155974
Uniprot IDs		P47989	A0A8V8TLS6 Q9Y3R0
PDB IDs		2CKJ 2E1Q	2JIL
Enriched GO Terms of Interacting Partners?		Endosome To Plasma Membrane Protein Transport Establishment Of Protein Localization To Postsynaptic Membrane Positive Regulation Of Neuron Projection Arborization Neurotransmitter Receptor Transport To Postsynaptic Membrane Neurotransmitter Receptor Transport To Plasma Membrane Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Regulation Of Neuron Projection Arborization Neurotransmitter Receptor Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Protein Localization To Postsynapse Signaling Receptor Complex Adaptor Activity Protein Localization To Postsynaptic Membrane Receptor Localization To Synapse Establishment Of Protein Localization To Plasma Membrane Protein Localization To Synapse Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels	Glutamate Receptor Signaling Pathway Regulation Of Cell Communication Glutamate-gated Receptor Activity Nuclear Receptor Activity Presynaptic Membrane Regulation Of Signaling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Positive Regulation Of Signal Transduction Chemical Synaptic Transmission Nuclear Receptor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Positive Regulation Of Intracellular Signal Transduction Synaptic Signaling Ligand-gated Monoatomic Ion Channel Activity Regulation Of Biological Quality Glutamate Receptor Activity Regulation Of Synaptic Transmission, Glutamatergic Cell-cell Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Synapse Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Transcription Coregulator Binding Cell Communication Hormone-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Postsynaptic Membrane Signal Transduction Nuclear Steroid Receptor Activity Postsynaptic Density Membrane AMPA Glutamate Receptor Activity Retinoic Acid Receptor Signaling Pathway MRNA Transcription Regulation Of Presynaptic Membrane Potential Regulation Of Synaptic Plasticity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Glutamatergic Synapse Regulation Of Signal Transduction Estrogen Response Element Binding
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