DIRAS3 and ACADM

Data Source: HiPPIP (Novel)

		DIRAS3	ACADM
Name		DIRAS family GTPase 3	acyl-CoA dehydrogenase medium chain
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Axon Mitochondrial Membrane
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding GDP Binding	Acyl-CoA Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Identical Protein Binding Flavin Adenine Dinucleotide Binding Medium-chain Fatty Acyl-CoA Dehydrogenase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Signal Transduction Small GTPase-mediated Signal Transduction Genomic Imprinting	Liver Development Glycogen Biosynthetic Process Organic Acid Metabolic Process Regulation Of Gluconeogenesis Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Beta-oxidation Heart Development Response To Cold Carnitine Metabolic Process Post-embryonic Development Carnitine Metabolic Process, CoA-linked Fatty Acid Beta-oxidation Using Acyl-CoA Dehydrogenase Response To Starvation Carnitine Biosynthetic Process Medium-chain Fatty Acid Metabolic Process Medium-chain Fatty Acid Catabolic Process Cardiac Muscle Cell Differentiation
Pathways		None	PPARA activates gene expression mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Drugs		None	Octanoyl-Coenzyme A Flavin adenine dinucleotide 3-thiaoctanoyl-CoA
Diseases		None	Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
GWAS		No GWAS studies recorded	Daytime sleep phenotypes ( 27126917 ) Glycine levels ( 30837465 31070104 ) Metabolic traits ( 21886157 ) Metabolite levels ( 20037589 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Serum metabolite levels ( 23093944 33031748 ) Serum metabolite ratios in chronic kidney disease ( 29545352 ) Urinary metabolite levels in chronic kidney disease ( 31959995 ) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995 )
Novel Interactors		2 novel interactors: ACADM HTR2A	5 novel interactors: ABCD3 AGTR1 DBT DIRAS3 MSH4
Interacting Genes		12 interacting genes: APC BAG4 BRMS1 CHEK2 FGFR4 KRAS MEOX2 PALB2 PPM1D PTPN1 TGFB1 WT1	5 interacting genes: CALM1 CDC42 DYNC1I1 PANK1 SUMO4
Entrez ID		9077	34
HPRD ID		05547	08447
Ensembl ID		ENSG00000162595	ENSG00000117054
Uniprot IDs		O95661	A0A0S2Z366 B4DJE7 B7Z9I1 P11310 Q5T4U5
PDB IDs		6NAZ	1EGC 1EGD 1EGE 1T9G 2A1T 4P13 8SGP
GO Terms Enriched among Interactors		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Protein-containing Complex Binding Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Anoikis Positive Regulation Of Macromolecule Metabolic Process Response To Nutrient Levels Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Macromolecule Metabolic Process Regulation Of Signaling Regulation Of Intracellular Signal Transduction Gland Development Regulation Of Cell Migration Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Fibroblast Migration Liver Development Regulation Of Protein Metabolic Process Regulation Of Cell Motility Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Locomotion Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Cell Population Proliferation Regulation Of Anoikis Morphogenesis Of A Branching Epithelium Pattern Specification Process Tissue Morphogenesis Morphogenesis Of A Branching Structure Negative Regulation Of Protein Serine/threonine Kinase Activity Response To Radiation Phosphate-containing Compound Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Apoptotic Process Regulation Of Kidney Development Apoptotic Process Regulation Of Fibroblast Migration Ureteric Bud Development Negative Regulation Of Programmed Cell Death	Intracellular Signaling Cassette Small GTPase-mediated Signal Transduction Angiotensin Type I Receptor Activity Bradykinin Receptor Binding Substantia Nigra Development Negative Regulation Of High Voltage-gated Calcium Channel Activity Neural Nucleus Development Regulation Of Cytokinesis Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Type II Interferon Cytoplasmic Ribonucleoprotein Granule GBD Domain Binding Storage Vacuole Organelle Transport Along Microtubule Dihydrolipoamide Branched Chain Acyltransferase Activity Recombination Nodule Phytanic Acid Metabolic Process Pantothenate Kinase Activity Angiotensin Type II Receptor Activity Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Organelle Localization Response To Type II Interferon Nucleotide Binding Apolipoprotein A-I Receptor Binding Endothelin Receptor Signaling Pathway Involved In Heart Process Neuropilin Signaling Pathway Branched-chain Alpha-keto Acid Decarboxylation To Branched-chain Acyl-CoA Branched-chain Alpha-ketoacid Dehydrogenase Complex Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid Import Into Peroxisome Acetyl-CoA Binding SUMO Ligase Complex