BEST1 and PPP2R5A

Number of citations of the paper that reports this interaction (PMID 12058047)
16

Data Source:
HPRD (in vivo, in vitro)

		BEST1	PPP2R5A
Gene Name		bestrophin 1	protein phosphatase 2, regulatory subunit B, alpha
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Chloride Channel Complex	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Cytoplasm Membrane Z Disc M Band
	Molecular Function	Chloride Channel Activity	Protein Binding Protein Phosphatase Type 2A Regulator Activity Kinase Binding
	Biological Process	Chloride Transport Visual Perception Transepithelial Chloride Transport Ion Transmembrane Transport Detection Of Light Stimulus Involved In Visual Perception Regulation Of Calcium Ion Transport Transmembrane Transport Chloride Transmembrane Transport	Signal Transduction Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Lipid Kinase Activity
Pathways		Ion channel transport Stimuli-sensing channels Orphan transporters	Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Estradiol levels ( 22675492) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		2 interactors: PPP2CA PPP2R5A	18 interactors: APC BCL2 BEST1 CHEK2 CSNK1A1 CTLA4 EIF2AK2 GNL3 JAK2 MAPT NEK1 NOS3 PPP2R1A PTTG1 PYGM SGOL1 SHC1 TP63
Entrez ID		7439	5525
HPRD ID		01094	03384
Ensembl ID		ENSG00000167995	ENSG00000066027
Uniprot IDs		B7Z1N8 B7Z375 O76090	Q15172
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Negative Regulation Of Lipid Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Mitotic Nuclear Envelope Reassembly Protein Heterotrimerization Nuclear Envelope Reassembly Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Autophosphorylation Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Inactivation Of MAPK Activity Positive Regulation Of Protein Metabolic Process Protein Trimerization Negative Regulation Of Stem Cell Differentiation Regulation Of Phosphorylation Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Dephosphorylation Regulation Of Protein Localization To Plasma Membrane Regulation Of Epithelial To Mesenchymal Transition Regulation Of Lipid Kinase Activity Nuclear Envelope Organization Negative Regulation Of Lipid Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of MAP Kinase Activity Regulation Of JAK-STAT Cascade Ceramide Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Regulation Of Receptor Activity Nucleus Organization Regulation Of Catalytic Activity Regulation Of DNA Replication Regulation Of Dephosphorylation Protein Heterooligomerization Negative Regulation Of Protein Serine/threonine Kinase Activity Second-messenger-mediated Signaling	Mitotic Cell Cycle Process Cell Division Organelle Organization Cellular Response To Stress Mitotic Cell Cycle Regulation Of Protein Metabolic Process Mitotic Nuclear Division Positive Regulation Of Signal Transduction Cell Cycle Process Regulation Of Cell Proliferation Cellular Response To DNA Damage Stimulus Regulation Of Catalytic Activity Cell Cycle Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Ionizing Radiation Apoptotic Process Positive Regulation Of Cell Death Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Phosphorus Metabolic Process Cell Death Negative Regulation Of Cell Proliferation Death Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Signal Transduction Response To Gamma Radiation Regulation Of Cell Differentiation Cytoskeleton Organization Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway Response To Radiation Regulation Of Kinase Activity Negative Regulation Of Mitotic Cell Cycle Regulation Of Signaling Cell Aging Regulation Of Cell Cycle Phase Transition Regulation Of Phosphorylation Protein Phosphorylation Intracellular Signal Transduction Negative Regulation Of Osteoblast Proliferation Positive Regulation Of Microtubule Polymerization Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Activation Of Protein Kinase Activity
Tagcloud ?		accumulate basolateral bestrophin ca centrifugation cl clarify compartment conducting counterion cytosolic degenerations endogenously helps influx knocked macular mandatory operated orai pigment porcine retinal rpe serca store stored stores vitelliforme
Tagcloud (Difference) ?		accumulate basolateral bestrophin ca centrifugation cl clarify compartment conducting counterion cytosolic degenerations endogenously helps influx knocked macular mandatory operated orai pigment porcine retinal rpe serca store stored stores vitelliforme
Tagcloud (Intersection) ?