BEST1 and PPP2R5A

Number of citations of the paper that reports this interaction (PubMedID 12058047)
0

Data Source:
HPRD (in vitro, in vivo)

		BEST1	PPP2R5A
Description		bestrophin 1	protein phosphatase 2 regulatory subunit B'alpha
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Chloride Channel Complex Presynapse Membrane Microdomain	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Z Disc M Band
	Molecular Function	Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Bicarbonate Transmembrane Transporter Activity Channel Activity Ligand-gated Channel Activity Identical Protein Binding Bicarbonate Channel Activity	Protein Binding Kinase Inhibitor Activity Protein Phosphatase Regulator Activity Kinase Binding Protein Phosphatase Activator Activity
	Biological Process	Monoatomic Ion Transport Chloride Transport Visual Perception Glutamate Secretion Bicarbonate Transport Transepithelial Chloride Transport Monoatomic Ion Transmembrane Transport Regulation Of Synaptic Plasticity Detection Of Light Stimulus Involved In Visual Perception Protein Complex Oligomerization Regulation Of Calcium Ion Transport Gamma-aminobutyric Acid Secretion, Neurotransmission Chloride Transmembrane Transport	Signal Transduction Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Stimuli-sensing channels	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation PKR-mediated signaling
Drugs
Diseases		Vitelliform macular dystrophy, including: Best disease / Juvenile vitelliform macular dystrophy (VMD2) ; Adult-onset vitelliform macular dystrophy (AVMD) Retinitis pigmentosa (RP) Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Aspartate aminotransferase levels ( 33547301) Estradiol levels ( 22675492) Metabolite levels ( 23823483) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335)	Deep white matter hyperintensities ( 32517579) HDL cholesterol levels ( 32203549) Nickel levels ( 26025379) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		4 interacting genes: FXYD6-FXYD2 MS4A13 PPP2CA PPP2R5A	28 interacting genes: APC AXIN2 BCL2 BEST1 BUB1B CDCA2 CHEK2 CSNK1A1 CTLA4 DAPK1 DZIP1 EIF2AK2 ERICH4 GNL3 JAK2 MAPT MOS NEK1 NOS3 PPFIA1 PPP2R1A PTTG1 SGO1 SHC1 SHFL TNNT2 TP63 USHBP1
Entrez ID		7439	5525
HPRD ID		01094	03384
Ensembl ID		ENSG00000167995	ENSG00000066027
Uniprot IDs		A0A0C4DGE9 A0A0S2Z4M4 A0A0S2Z579 B7Z375 O76090	Q15172
PDB IDs		8D1I 8D1J 8D1K 8D1L 8D1M 8D1O 9CTQ 9CTR 9CTS 9CTT 9DYL 9DYM	6NTS 8SZK
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Chromosome, Centromeric Region RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Kinase Inhibitor Activity Protein Serine/threonine Phosphatase Complex Peptidyl-threonine Dephosphorylation INTAC Complex Vascular Endothelial Cell Response To Fluid Shear Stress GABA Receptor Binding FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Response To Lead Ion Protein Phosphatase Activator Activity RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Negative Regulation Of ATP Metabolic Process M Band Cellular Response To Fluid Shear Stress Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Protein Localization To Plasma Membrane	Cell Division Organelle Organization Protein Serine Kinase Activity Protein Kinase Activity Regulation Of Chromosome Organization Regulation Of Cell Cycle Process Protein Serine/threonine Kinase Activity Kinase Activity Beta-catenin Destruction Complex Negative Regulation Of Osteoblast Proliferation Protein Phosphorylation Regulation Of Organelle Organization Protein Autophosphorylation Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Cellular Component Organization Phosphorylation Chromosome Segregation Regulation Of Nuclear Division Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Cytosol Kinetochore Chromosome, Centromeric Region Centrosome Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Meiotic Sister Chromatid Cohesion, Centromeric Regulation Of Osteoblast Proliferation Regulation Of Protein Metabolic Process Chromosome Organization Negative Regulation Of Cell Cycle Cytoskeleton Organization Negative Regulation Of Cell Cycle Phase Transition Protein Phosphatase Regulator Activity Regulation Of Mitotic Nuclear Division Sister Chromatid Cohesion Regulation Of Cell Cycle Phase Transition Cytoskeleton Microtubule Cytoskeleton Organization Nuclear Chromosome Segregation Chromosome Signal Transduction Nucleus Axon Development Regulation Of Cell Communication Cytoplasm Regulation Of Signal Transduction Regulation Of Signaling
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