BEST1 and MS4A13

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BEST1	MS4A13
Description		bestrophin 1	membrane spanning 4-domains A13
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Chloride Channel Complex Presynapse Membrane Microdomain	Plasma Membrane Membrane
	Molecular Function	Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Protein Binding Bicarbonate Transmembrane Transporter Activity Channel Activity Ligand-gated Channel Activity Identical Protein Binding Bicarbonate Channel Activity	Protein Binding
	Biological Process	Monoatomic Ion Transport Chloride Transport Visual Perception Glutamate Secretion Bicarbonate Transport Transepithelial Chloride Transport Monoatomic Ion Transmembrane Transport Regulation Of Synaptic Plasticity Detection Of Light Stimulus Involved In Visual Perception Protein Complex Oligomerization Regulation Of Calcium Ion Transport Gamma-aminobutyric Acid Secretion, Neurotransmission Chloride Transmembrane Transport	Cell Surface Receptor Signaling Pathway
Pathways		Stimuli-sensing channels
Drugs
Diseases		Vitelliform macular dystrophy, including: Best disease / Juvenile vitelliform macular dystrophy (VMD2) ; Adult-onset vitelliform macular dystrophy (AVMD) Retinitis pigmentosa (RP) Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
GWAS		Aspartate aminotransferase levels ( 33547301) Estradiol levels ( 22675492) Metabolite levels ( 23823483) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Red blood cell fatty acid levels ( 25500335)	Congenital heart disease (maternal effect) ( 28468790) Major depressive disorder ( 29317602) Metabolite levels (X-11787) ( 23934736)
Interacting Genes		4 interacting genes: FXYD6-FXYD2 MS4A13 PPP2CA PPP2R5A	63 interacting genes: AQP2 AQP6 ASGR2 ATP6V0E1 BEST1 BIK CBARP CD79A CLDN7 CREB3L1 CREB3L3 DAGLA EBP EDA EREG ERGIC3 EVA1A FAM209A FAM210B FFAR2 GJA4 GJA5 GJA8 GJB1 GJB5 GJB6 GJC3 GPR152 GPR42 HERPUD2 JSRP1 KCNMB4 KLRC1 LHFPL5 LRRC3B MMGT1 MS4A3 NPDC1 ODF4 POMK RAMP1 RHCG RNF185 SCN3B SLC10A6 SLC12A7 SLC13A4 SLC16A2 SLC18A1 SLC30A2 SLC39A2 SLC7A1 SPAG4 SSMEM1 TBXA2R TLCD4 TM4SF18 TMC4 TMEM14B TMEM237 TMEM52B TMEM74 VSIR
Entrez ID		7439	503497
HPRD ID		01094	17604
Ensembl ID		ENSG00000167995	ENSG00000204979
Uniprot IDs		A0A0C4DGE9 A0A0S2Z4M4 A0A0S2Z579 B7Z375 O76090	Q5J8X5
PDB IDs		8D1I 8D1J 8D1K 8D1L 8D1M 8D1O 9CTQ 9CTR 9CTS 9CTT 9DYL 9DYM
Enriched GO Terms of Interacting Partners?		Protein Phosphatase Type 2A Complex RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Chromosome, Centromeric Region RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress Kinase Inhibitor Activity Protein Serine/threonine Phosphatase Complex Peptidyl-threonine Dephosphorylation INTAC Complex Vascular Endothelial Cell Response To Fluid Shear Stress GABA Receptor Binding FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Response To Lead Ion Protein Phosphatase Activator Activity RNA Polymerase II Transcription Initiation Surveillance Negative Regulation Of Hippo Signaling Negative Regulation Of ATP Metabolic Process M Band Cellular Response To Fluid Shear Stress Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Protein Localization To Plasma Membrane	Membrane Transmembrane Transport Connexin Complex Gap Junction Channel Activity Gap Junction Plasma Membrane Monoatomic Ion Transport Protein Binding Inorganic Ion Transmembrane Transport Gap Junction Assembly Cell-cell Signaling Inorganic Cation Transmembrane Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Signaling Cell Communication Metal Ion Transport Cell Communication By Electrical Coupling Inorganic Anion Transmembrane Transport Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell-cell Junction Assembly Anchoring Junction Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Inorganic Anion Transport SA Node Cell Action Potential Gap Junction-mediated Intercellular Transport AV Node Cell To Bundle Of His Cell Communication Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Renal Water Transport Endoplasmic Reticulum Membrane Channel Activity Monoatomic Cation Transmembrane Transport Ammonium Channel Activity Chloride Transmembrane Transport Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Transmembrane Transporter Activity Cell-cell Junction Organization Ammonium Transmembrane Transport Intercellular Transport Chloride Transport System Process Amine Transport Transport Vesicle Membrane Water Channel Activity Monoatomic Anion Transmembrane Transport Carbon Dioxide Transport Cell Communication By Electrical Coupling Involved In Cardiac Conduction
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